Cyclic Dichalcogenides Extend the Reach of Bioreductive Prodrugs to Harness Thiol/Disulfide Oxidoreductases: Applications to seco-Duocarmycins Targeting the Thioredoxin System
Sign Up to like & getrecommendations! Published in 2023 at "ACS Central Science"
DOI: 10.1021/acscentsci.2c01465
Abstract: Small-molecule prodrug approaches that can activate cancer therapeutics selectively in tumors are urgently needed. Here, we developed the first antitumor prodrugs designed for activation by thiol-manifold oxidoreductases, targeting the thioredoxin (Trx) system. The Trx system… read more here.
Keywords: thiol; system; cyclic dichalcogenides; bioreductive prodrugs ... See more keywords
Novel strategies for targeting the thioredoxin system for cancer therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Expert opinion on drug discovery"
DOI: 10.1080/17460441.2022.2045270
Abstract: INTRODUCTION : The thioredoxin system is increasingly recognized as an important executor for maintaining cell redox homeostasis and regulating multiple cell signaling pathways. Targeting this system for cancer treatment has therefore attracted much attention. AREAS… read more here.
Keywords: system cancer; system; thioredoxin system; targeting thioredoxin ... See more keywords