Targeting TP53-Mutated Acute Myeloid Leukemia: Research and Clinical Developments
Sign Up to like & getrecommendations! Published in 2022 at "OncoTargets and therapy"
DOI: 10.2147/ott.s265637
Abstract: Abstract TP53 is a key tumor suppressor gene that plays an important role in regulating apoptosis, senescence, and DNA damage repair in response to cellular stress. Although somewhat rare, TP53-mutated AML has been identified as… read more here.
Keywords: mutated acute; myeloid leukemia; targeting tp53; acute myeloid ... See more keywords
Amomum subulatum: A treasure trove of anti-cancer compounds targeting TP53 protein using in vitro and in silico techniques
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2023.1174363
Abstract: Cancer is a primary global health concern, and researchers seek innovative approaches to combat the disease. Clinical bioinformatics and high-throughput proteomics technologies provide powerful tools to explore cancer biology. Medicinal plants are considered effective therapeutic… read more here.
Keywords: subulatum seeds; targeting tp53; amomum subulatum; tp53 ... See more keywords
MiR-31a-5p protects myocardial cells against apoptosis by targeting Tp53.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular medicine reports"
DOI: 10.3892/mmr.2017.8357
Abstract: The pathogenesis and progression of heart failure (HF) involves multiple mechanisms, including the increased activity of the renin-angiotensin-aldosterone system, apoptosis and differential expression of microRNAs (miRNAs/miRs). Our previous study revealed an increase in miR‑31a‑5p levels… read more here.
Keywords: myocardial cells; seed; mir 31a; targeting tp53 ... See more keywords