Novel diaryl-2H-azirines: Antitumor hybrids for dual-targeting tubulin and DNA.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113256
Abstract: Multiple-target drugs may achieve better therapeutic effect via different pathways than single-target ones, especially for complex diseases. Tubulin and DNA are well-characterized molecular targets for anti-cancer drug development. A novel class of diaryl substituted 2H-azirines… read more here.
Keywords: novel diaryl; targeting tubulin; tubulin dna; dna ... See more keywords
Indole-based, Antiproliferative Agents Targeting Tubulin Polymerization.
Sign Up to like & getrecommendations! Published in 2017 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026616666160530154812
Abstract: Indole is a potential lead for drug design which has been found in numerous pharmaceutically important compounds due to its medicinal properties, such as anti-tumor, anti-bacterial, anti-virus and anti-inflammatory. In the last decade, interfering with… read more here.
Keywords: targeting tubulin; polymerization; tubulin polymerization; agents targeting ... See more keywords
Selection and Characterization of Artificial Proteins Targeting the Tubulin alpha Subunit.
Sign Up to like & getrecommendations! Published in 2019 at "Structure"
DOI: 10.2210/pdb6gwd/pdb
Abstract: Summary Microtubules are cytoskeletal filaments of eukaryotic cells made of αβ-tubulin heterodimers. Structural studies of non-microtubular tubulin rely mainly on molecules that prevent its self-assembly and are used as crystallization chaperones. Here we identified artificial… read more here.
Keywords: targeting tubulin; artificial proteins; microtubule; selection characterization ... See more keywords
A Review of the Recent Developments of Molecular Hybrids Targeting Tubulin Polymerization
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23074001
Abstract: Microtubules are cylindrical protein polymers formed from αβ-tubulin heterodimers in the cytoplasm of eukaryotic cells. Microtubule disturbance may cause cell cycle arrest in the G2/M phase, and anomalous mitotic spindles will form. Microtubules are an… read more here.
Keywords: molecular hybrids; targeting tubulin; review recent; tubulin polymerization ... See more keywords