Targeting Tumor‐Associated Antigens in Hepatocellular Carcinoma for Immunotherapy: Past Pitfalls and Future Strategies
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31502
Abstract: There are few treatment options for advanced-stage hepatocellular carcinoma (HCC). Targeting tumor-associated antigens (TAAs) for HCC immunotherapy has been tested clinically for many years with limited success. Recent advances in applying mutated tumor-specific neoantigens as… read more here.
Keywords: hepatocellular carcinoma; immunotherapy; targeting tumor; tumor associated ... See more keywords
In situ antitumor vaccination: Targeting the tumor microenvironment
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29551
Abstract: Tumor microenvironment is known to play important roles in tumor progression. Many therapies, targeting the tumor microenvironment, are designed and applied in the clinic. One of these approaches is in situ antitumor therapy. This way,… read more here.
Keywords: situ antitumor; targeting tumor; tumor microenvironment; tumor ... See more keywords
Precision targeting tumor cells using cancer-specific InDel mutations with CRISPR-Cas9
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2103532119
Abstract: Significance The targeted killing of cancer cells without affecting surrounding normal cells is the most desirable approach for cancer therapy; however, it cannot be easily achieved, owing to the shared properties of normal and cancer… read more here.
Keywords: cancer; cells using; cancer specific; crispr cas9 ... See more keywords
Targeting tumor-associated macrophages for successful immunotherapy of ovarian carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005968
Abstract: Epithelial ovarian cancer (EOC) is among the top five causes of cancer-related death in women, largely reflecting early, prediagnosis dissemination of malignant cells to the peritoneum. Despite improvements in medical therapies, particularly with the implementation… read more here.
Keywords: targeting tumor; tumor associated; immunotherapy; associated macrophages ... See more keywords
Abstract B199: Targeting the tumor microenvironment with first-in-class Semaphorin4D MAb for combination immunotherapy
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-17-b199
Abstract: Purpose: Mechanistic findings in preclinical studies demonstrate that antibody blockade of Semaphorin 4D (SEMA4D, CD100) reduces expansion of MDSC and shifts the balance of immune cells within the TME to facilitate tumor rejection. Efficacy is… read more here.
Keywords: combination; targeting tumor; microenvironment first; first class ... See more keywords
Abstract 1599: Targeting tumor synthetic vulnerabilities and immune evasion mechanisms with CO-1002
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1599
Abstract: Cancer immunotherapy with immune checkpoint inhibitors (ICI) has shown durable clinical benefits in patients with immune-hot tumors. However, the majority of cancers are characterized by an immune-cold tumor microenvironment, which are refractory to ICI therapy.… read more here.
Keywords: tumor synthetic; targeting tumor; evasion; synthetic vulnerabilities ... See more keywords
Targeting tumor-associated macrophage (TAM) mediated inhibition of T-cell migration in prostate cancer using epigenetic modifying agents.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.6_suppl.166
Abstract: 166Background: Cytotoxic T lymphocytes (CTLs) perform vital anti-tumor functions and are critical to the efficacy of many anticancer therapies. In prostate cancer, the characteristic paucity of act... read more here.
Keywords: targeting tumor; tumor associated; prostate cancer; associated macrophage ... See more keywords
Selective targeting of tumor associated macrophages in different tumor models
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DOI: 10.1371/journal.pone.0193015
Abstract: Tumor progression largely depends on the presence of alternatively polarized (M2) tumor-associated macrophages (TAMs), whereas the classical M1-polarized macrophages can promote anti-tumorigenic immune responses. Thus, selective inhibition of M2-TAMs is a desirable anti-cancer approach in… read more here.
Keywords: m2pep; different tumor; tumor associated; targeting tumor ... See more keywords
"Cor Occidere": a novel strategy of targeting the tumor core by radiosurgery in a radio- and chemo-resistant intracranial hemangiopericytoma.
Sign Up to like & getrecommendations! Published in 2018 at "Chinese clinical oncology"
DOI: 10.21037/cco.2018.01.02
Abstract: Intracranial hemangiopericytomas (HPC) are chemotherapy- and radiotherapy (RT)-resistant. Here, we report on a novel stereotactic radiosurgery (SRS) technique-"Cor Occidere" (Latin), as a potential strategy of overcoming radioresistance of HPC. A 36-year old female presented to… read more here.
Keywords: targeting tumor; tumor core; radiosurgery; cor occidere ... See more keywords
Targeting tumor-associated macrophages for the immunotherapy of glioblastoma: Navigating the clinical and translational landscape
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1024921
Abstract: Tumor-associated macrophages (TAMs) can directly clear tumor cells and enhance the phagocytic ability of immune cells. An abundance of TAMs at the site of the glioblastoma tumor indicates that TAM-targeting immunotherapy could represent a potential… read more here.
Keywords: targeting tumor; glioblastoma; macrophages immunotherapy; associated macrophages ... See more keywords
Therapeutic Targeting of Tumor Cells and Tumor Immune Microenvironment Vulnerabilities
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.816504
Abstract: Therapeutic targeting of tumor vulnerabilities is emerging as a key area of research. This review is focused on exploiting the vulnerabilities of tumor cells and the immune cells in the tumor immune microenvironment (TIME), including… read more here.
Keywords: cancer; targeting tumor; tumor cells; therapeutic targeting ... See more keywords