Targeting type H vessels in bone‐related diseases
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.18123
Abstract: Blood vessels are essential for bone development and metabolism. Type H vessels in bone, named after their high expression of CD31 and Endomucin (Emcn), have recently been reported to locate mainly in the metaphysis, exhibit… read more here.
Keywords: vessels bone; bone related; type; type vessels ... See more keywords
Mitochondria-Targeting Type-I Photodynamic Therapy Based on Phenothiazine for Realizing Enhanced Immunogenic Cancer Cell Death via Mitochondrial Oxidative Stress
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s494970
Abstract: Purpose Photo-immunotherapy faces challenges from poor immunogenicity and low response rate due to hypoxic microenvironment. This study presents Rh-PTZ, a small organic molecule with a D-π-A structure, that simultaneously amplifies mitochondria-targeted type-I PDT-dependent immune stimulation… read more here.
Keywords: cancer; stress; mitochondria targeting; ptz ... See more keywords
Targeting type I interferons in systemic lupus erythematous
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1046687
Abstract: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with systemic clinical manifestations including, but not limited to, rash, inflammatory arthritis, serositis, glomerulonephritis, and cerebritis. Treatment options for SLE are expanding and the increase in… read more here.
Keywords: type ifn; systemic lupus; targeting type; type interferons ... See more keywords
Therapeutic Potential for Intractable Asthma by Targeting L-Type Amino Acid Transporter 1
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DOI: 10.3390/biom12040553
Abstract: Bronchial asthma is a chronic disease characterized by airway inflammation, obstruction, and hyperresponsiveness. CD4+ T cells, particularly T helper (Th) 2 cells, and their specific cytokines are important mediators in asthma pathogenesis. However, it has… read more here.
Keywords: type amino; asthma; acid transporter; amino acid ... See more keywords
Strategies Targeting Type 2 Inflammation: From Monoclonal Antibodies to JAK-Inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Biomedicines"
DOI: 10.3390/biomedicines9101497
Abstract: Bronchial asthma and its frequent comorbidity chronic rhinosinusitis (CRS), are characterized by an inflammatory process at lower and upper respiratory tract, with a variability in terms of clinical presentations (phenotypes) and distinct underpin pathophysiological mechanisms… read more here.
Keywords: monoclonal antibodies; targeting type; strategies targeting; inflammatory process ... See more keywords