Targeting ubiquitin protein ligase E3 component N-recognin 5 in cancer cells induces a CD8+ T cell mediated immune response
Sign Up to like & getrecommendations! Published in 2020 at "Oncoimmunology"
DOI: 10.1080/2162402x.2020.1746148
Abstract: ABSTRACT UBR5 is a nuclear phosphoprotein of obscure functions. Clinical analyses reveal that UBR5 amplifications and overexpression occur in over 20% cases of human breast cancers. Breast cancer patients carrying UBR5 genetic lesions with overexpression… read more here.
Keywords: ubiquitin protein; response; protein ligase; cancer ... See more keywords
Prevalence of antibodies targeting ubiquitin-conjugating enzyme 2L3 and eukaryote translation elongation factor 1 α1 in Chinese Han and American Caucasian populations with type 1 diabetes
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DOI: 10.1530/ec-22-0325
Abstract: We assessed the prevalence of two novel islet autoantibodies, those targeting ubiquitin-conjugating enzyme 2L3 (UBE2L3) and eukaryote translation elongation factor 1 α1 (eEF1A1), in type 1 diabetes mellitus (T1DM) to evaluate their utility in T1DM… read more here.
Keywords: american caucasian; targeting ubiquitin; prevalence; conjugating enzyme ... See more keywords
Targeting the Ubiquitin System in Glioblastoma
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DOI: 10.3389/fonc.2020.574011
Abstract: Glioblastoma is the most common primary brain tumor in adults with poor overall outcome and 5-year survival of less than 5%. Treatment has not changed much in the last decade or so, with surgical resection… read more here.
Keywords: system; glioblastoma; system glioblastoma; targeting ubiquitin ... See more keywords
Targeting Ubiquitin-Proteasome Pathway by Natural Products: Novel Therapeutic Strategy for Treatment of Neurodegenerative Diseases
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DOI: 10.3389/fphys.2020.00361
Abstract: Misfolded proteins are the main common feature of neurodegenerative diseases, thereby, normal proteostasis is an important mechanism to regulate the neural survival and the central nervous system functionality. The ubiquitin-proteasome system (UPS) is a non-lysosomal… read more here.
Keywords: system; proteasome pathway; targeting ubiquitin; neurodegenerative diseases ... See more keywords