Targeting viral proteins for restraining SARS-CoV-2: focusing lens on viral proteins beyond spike for discovering new drug targets
Sign Up to like & getrecommendations! Published in 2023 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2023.2175812
Abstract: ABSTRACT Introduction Emergence of highly infectious SARS-CoV-2 variants are reducing protection provided by current vaccines, requiring constant updates in antiviral approaches. The virus encodes four structural and sixteen nonstructural proteins which play important roles in… read more here.
Keywords: viral proteins; targeting viral; proteins restraining; restraining sars ... See more keywords
Targeting viral entry as a strategy for broad-spectrum antivirals
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DOI: 10.12688/f1000research.19694.1
Abstract: The process of entry into a host cell is a key step in the life cycle of most viruses. In recent years, there has been a significant increase in our understanding of the routes and… read more here.
Keywords: entry strategy; targeting viral; entry; broad spectrum ... See more keywords
Progression of Antiviral Agents Targeting Viral Polymerases
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DOI: 10.3390/molecules27217370
Abstract: Viral DNA and RNA polymerases are two kinds of very important enzymes that synthesize the genetic materials of the virus itself, and they have become extremely favorable targets for the development of antiviral drugs because… read more here.
Keywords: viral polymerases; antiviral agents; targeting viral; progression antiviral ... See more keywords
Targeting Viral Ion Channels: A Promising Strategy to Curb SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15040396
Abstract: SARS-CoV-2 is the etiological agent COVID-19, one of the most impactful health crises afflicting humanity in recent decades. While research advances have yielded several treatment and prevention options, the pandemic is slow to abate, necessitating… read more here.
Keywords: curb; targeting viral; ion; viral ion ... See more keywords