Targeting Wnt/β-Catenin Signaling for Cancer Immunotherapy.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2018.03.008
Abstract: Despite the dramatic antitumor efficiency of certain immune checkpoint inhibitors, immunotherapy has met a bottleneck regarding the response rate and resistance in cancer patients. Increasing evidence indicates that Wnt/β-catenin signaling, one of the best-characterized cancer… read more here.
Keywords: targeting wnt; immunotherapy; catenin signaling; cancer ... See more keywords
Rationale for targeting the Wnt signalling modulator Dickkopf‐1 for oncology
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Pharmacology"
DOI: 10.1111/bph.13894
Abstract: Wnt signalling is a fundamental pathway involved in embryonic development and adult tissue homeostasis. Mutations in the pathway frequently lead to developmental defects and cancer. As such, therapeutic intervention of this pathway has generated tremendous… read more here.
Keywords: targeting wnt; rationale targeting; dickkopf; wnt signalling ... See more keywords
Targeting Wnt signaling pseudokinases in hematological cancers
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Haematology"
DOI: 10.1111/ejh.13137
Abstract: Recent studies showed that several pseudokinases from the receptor tyrosine kinase family are important players in regulating cancer cell invasion, metastasis, and drug resistance, suggesting that targeting these proteins can play a therapeutic role in… read more here.
Keywords: targeting wnt; wnt signaling; kinase; signaling pseudokinases ... See more keywords
Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0229445
Abstract: The Wnt/β-catenin signaling pathway has been implicated in human proliferative diseases such as cancer and fibrosis. The functions of β-catenin and several other components of this pathway have been investigated in fibrosis. However, the potential… read more here.
Keywords: targeting wnt; fibrosis; signaling pathway; strategy ... See more keywords
Editorial: Targeting the Wnt/β-catenin signaling pathway in cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1022174
Abstract: COPYRIGHT © 2022 Patergnani, Buchsbaum and Piazza. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided… read more here.
Keywords: pathway cancer; signaling pathway; targeting wnt; wnt catenin ... See more keywords
Targeting Wnt Signaling via Notch in Intestinal Carcinogenesis
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DOI: 10.3390/cancers11040555
Abstract: Proliferation and differentiation of intestinal epithelial cells is assisted by highly specialized and well-regulated signaling cascades. The Wnt pathway, which is one of the fundamental pathways in the intestine, contributes to the organization of proliferative… read more here.
Keywords: targeting wnt; wnt signaling; via notch; signaling via ... See more keywords
Targeting Wnt Signaling for Gastrointestinal Cancer Therapy: Present and Evolving Views
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DOI: 10.3390/cancers12123638
Abstract: Simple Summary Therapeutic targeting of Wnt has long been suggested for gastrointestinal (GI) cancer treatment because deregulation of Wnt signaling is associated with GI cancers. However, therapeutic targeting of Wnt is still challenging because of… read more here.
Keywords: targeting wnt; wnt signaling; evolving views; gastrointestinal cancer ... See more keywords