In Vitro Evaluation of Candidate Gene Targets for Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9220-1_2
Abstract: Discovery and development of gene targets for cancer therapeutics are lengthy and highly costly processes. Identification and evaluation of candidate gene targets are of fundamental importance. RNA interference allows candidate genes to be specifically and… read more here.
Keywords: gene targets; targets cancer; candidate gene; cancer ... See more keywords
Therapeutic targets of cancer drugs: Modulation by melatonin.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118934
Abstract: The biological functions of melatonin range beyond the regulation of circadian rhythms. With regard to cancer, melatonin's potential to suppress cancer initiation, progression, angiogenesis and metastasis as well as sensitizing malignant cells to conventional chemo-… read more here.
Keywords: cancer drugs; cancer effects; targets cancer; cancer ... See more keywords
New emerging targets in cancer immunotherapy: the role of TIM3
Sign Up to like & getrecommendations! Published in 2019 at "ESMO Open"
DOI: 10.1136/esmoopen-2019-000497
Abstract: Currently, the programmed death-1/programmed death ligand-1 and the cytotoxic T-lymphocyte-associated protein 4 are the two commonly targeted immune-checkpoint inhibition pathways. These drugs have significantly improved the prognosis of many cancer types. While immune-checkpoint inhibitors have… read more here.
Keywords: immune checkpoint; targets cancer; checkpoint; cancer ... See more keywords
New emerging targets in cancer immunotherapy beyond CTLA-4, PD-1 and PD-L1: Introducing an “ESMO Open – Cancer Horizons” Series
Sign Up to like & getrecommendations! Published in 2019 at "ESMO Open"
DOI: 10.1136/esmoopen-2019-000501
Abstract: The ability of tumour cells to escape the surveillance and elimination by the immune system represents one of the hallmarks of cancer.1 2 This concept of immune control against cancer development, recognised more than 60… read more here.
Keywords: esmo open; targets cancer; cancer immunotherapy; cancer ... See more keywords
Myokines as Possible Therapeutic Targets in Cancer Cachexia
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Immunology Research"
DOI: 10.1155/2018/8260742
Abstract: Cachexia is an extremely serious syndrome which occurs in most patients with different cancers, and it is characterized by systemic inflammation, a negative protein and energy balance, and involuntary loss of body mass. This syndrome… read more here.
Keywords: therapeutic targets; targets cancer; myokines possible; cancer cachexia ... See more keywords
The PROTAC DT2216 Targets Cancer by Promoting BCL-XL Degradation.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2019-185
Abstract: DT2216, a proteolysis-targeting chimera (PROTAC), effectively targets BCL-XLfor degradation. read more here.
Keywords: protac; protac dt2216; dt2216 targets; targets cancer ... See more keywords
The emerging role of deubiquitylating enzymes as therapeutic targets in cancer metabolism
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Cell International"
DOI: 10.1186/s12935-022-02524-y
Abstract: Cancer cells must rewire cellular metabolism to satisfy the unbridled proliferation, and metabolic reprogramming provides not only the advantage for cancer cell proliferation but also new targets for cancer treatment. However, the plasticity of the… read more here.
Keywords: cancer; cancer cell; targets cancer; cancer metabolism ... See more keywords
Distinct functions of dynamin isoforms in tumorigenesis and their potential as therapeutic targets in cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.16678
Abstract: Dynamins and their related proteins participate in the regulation of neurotransmission, antigen presentation, receptor internalization, growth factor signalling, nutrient uptake, and pathogen infection. Recently, emerging findings have shown dynamin proteins can also contribute to the… read more here.
Keywords: functions dynamin; therapeutic targets; distinct functions; targets cancer ... See more keywords
Immunoregulatory antigens-novel targets for cancer immunotherapy.
Sign Up to like & getrecommendations! Published in 2018 at "Chinese clinical oncology"
DOI: 10.21037/cco.2018.01.03
Abstract: Historically, the development of cancer vaccines has focused on the central role of tumor antigens in eliciting tumor-specific immune responses, with limited success. Recent advances with checkpoint blockade approaches have brought about a renewed appreciation… read more here.
Keywords: immunoregulatory antigens; targets cancer; cancer immunotherapy; cancer ... See more keywords
Phosphoenolpyruvate carboxykinases as emerging targets in cancer therapy
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1196226
Abstract: Metabolic reprogramming is commonly accompanied by alterations in the expression of metabolic enzymes. These metabolic enzymes not only catalyze the intracellular metabolic reaction, but also participate in a series of molecular events to regulate tumor… read more here.
Keywords: carboxykinases emerging; targets cancer; phosphoenolpyruvate; cancer therapy ... See more keywords
Proteoglycans—Biomarkers and Targets in Cancer Therapy
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2018.00069
Abstract: Proteoglycans (PGs), important constituents of the extracellular matrix, have been associated with cancer pathogenesis. Their unique structure consisting of a protein core and glycosaminoglycan chains endowed with fine modifications constitutes these molecules as capable cellular… read more here.
Keywords: therapy; biomarkers targets; targets cancer; cancer ... See more keywords