Lipoxygenases as Targets for Drug Development.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0163-1_17
Abstract: Lipoxygenases are key enzymes that catalyze the polyunsaturated fatty acids such as arachidic acid, linoleic acid (LA), and others unsaturated fatty acids. They are involved in important functions such as cell structure, metabolism, and signal… read more here.
Keywords: drug development; targets drug; biology; lipoxygenases targets ... See more keywords
Heterotrimeric G Proteins as Therapeutic Targets in Drug Discovery.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b01452
Abstract: Heterotrimeric G proteins are molecular switches in GPCR signaling pathways and regulate a plethora of physiological and pathological processes. GPCRs are efficient drug targets and more than 30% of the drugs in use target them.… read more here.
Keywords: targets drug; therapeutic targets; drug; heterotrimeric proteins ... See more keywords
“Upcycling” known molecules and targets for drug-resistant TB
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.1029044
Abstract: Despite reinvigorated efforts in Tuberculosis (TB) drug discovery over the past 20 years, relatively few new drugs and candidates have emerged with clear utility against drug resistant TB. Over the same period, significant technological advances… read more here.
Keywords: upcycling known; targets drug; known molecules; molecules targets ... See more keywords
G-Quadruplex-Binding Proteins: Promising Targets for Drug Design
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12050648
Abstract: G-quadruplexes (G4s) are non-canonical secondary nucleic acid structures. Sequences with the potential to form G4s are abundant in regulatory regions of the genome including telomeres, promoters and 5′ non-coding regions, indicating they fulfill important genome… read more here.
Keywords: quadruplex binding; promising targets; targets drug; binding proteins ... See more keywords
GPCRs in Intracellular Compartments: New Targets for Drug Discovery
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DOI: 10.3390/biom12101343
Abstract: The architecture of eukaryotic cells is defined by extensive membrane-delimited compartments, which entails separate metabolic processes that would otherwise interfere with each other, leading to functional differences between cells. G protein-coupled receptors (GPCRs) are the… read more here.
Keywords: gpcrs intracellular; cell; new targets; targets drug ... See more keywords
Aquaporins in Immune Cells and Inflammation: New Targets for Drug Development
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22041845
Abstract: The mammalian immune system senses foreign antigens by mechanisms that involve the interplay of various kinds of immune cells, culminating in inflammation resolution and tissue clearance. The ability of the immune cells to communicate (via… read more here.
Keywords: targets drug; inflammation new; immune cells; cells inflammation ... See more keywords