Genome-wide off-targets of drugs: risks and opportunities
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-019-09491-7
Abstract: Most approved drugs and small-molecule compounds modulate their therapeutic and toxic effects through multiple protein targets and biological pathways. Proteome-wide compound-target interaction networks (among both onand off-targets) are therefore essential resources to better understand and… read more here.
Keywords: genome wide; wide targets; drugs risks; targets drugs ... See more keywords
Biochemical targets of drugs mitigating oxidative stress via redox-independent mechanisms.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Society transactions"
DOI: 10.1042/bst20160473
Abstract: Acute or chronic oxidative stress plays an important role in many pathologies. Two opposite approaches are typically used to prevent the damage induced by reactive oxygen and nitrogen species (RONS), namely treatment either with antioxidants… read more here.
Keywords: drugs mitigating; redox; targets drugs; stress ... See more keywords