New targets for HIV drug discovery.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.03.013
Abstract: Recent estimates suggest close to one million people per year die globally owing to HIV-related illnesses. Therefore, there is still a need to identify new targets to develop future treatments. Many of the more recently… read more here.
Keywords: targets hiv; drug; new targets; hiv drug ... See more keywords
Finding host targets for HIV therapy
Sign Up to like & getrecommendations! Published in 2017 at "Nature Genetics"
DOI: 10.1038/ng.3777
Abstract: A CRISPR screen conducted in a CD4+ T cell leukemia line has identified host factors required for HIV infection but dispensable for cellular survival. The results highlight sulfation on the HIV co-receptor CCR5 and cellular… read more here.
Keywords: host targets; targets hiv; finding host; hiv therapy ... See more keywords
Molecular docking, QSAR and ADMET based mining of natural compounds against prime targets of HIV
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2017.1420489
Abstract: AIDS is one of the multifaceted diseases and this underlying complexity hampers its complete cure. The toxicity of existing drugs and emergence of multidrug-resistant virus makes the treatment worse. Development of effective, safe and low-cost… read more here.
Keywords: qsar admet; targets hiv; treatment; docking qsar ... See more keywords