Discovery of Targets for Immune–Metabolic Antitumor Drugs Identifies Estrogen-Related Receptor Alpha
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Discovery"
DOI: 10.1158/2159-8290.cd-22-0244
Abstract: The computational tool BipotentR was used to reveal drug targets that can inhibit tumor growth by concurrent immune activation and inhibition of a separate oncogenic pathway, leading to identification of ESRRA as a top immune–metabolic… read more here.
Keywords: discovery targets; immune metabolic; targets immune; metabolic antitumor ... See more keywords
Novel Therapeutic Targets and Immune Dysfunction in Malignant Pleural Mesothelioma
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.806570
Abstract: Advances in the treatment of malignant pleural mesothelioma (MPM) have been disappointing, despite the apparent need for new therapeutic options for this rare and devastating cancer. Drug resistance is common and surgical intervention has brought… read more here.
Keywords: pleural mesothelioma; therapeutic targets; targets immune; novel therapeutic ... See more keywords
Cysteine Cathepsins as Therapeutic Targets in Immune Regulation and Immune Disorders
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11020476
Abstract: Cysteine cathepsins, as the most abundant proteases found in the lysosomes, play a vital role in several processes—such as protein degradation, changes in cell signaling, cell morphology, migration and proliferation, and energy metabolism. In addition… read more here.
Keywords: cathepsins therapeutic; cysteine cathepsins; immune disorders; targets immune ... See more keywords