The polyphenol EGCG directly targets intracellular amyloid-β aggregates and promotes their lysosomal degradation.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neurochemistry"
DOI: 10.1111/jnc.15842
Abstract: The accumulation of amyloidogenic protein aggregates in neurons is a pathogenic hallmark of a large number of neurodegenerative diseases including Alzheimer's disease (AD). Small molecules targeting such structures and promoting their degradation may have therapeutic… read more here.
Keywords: egcg directly; directly targets; amyloid aggregates; lysosomal degradation ... See more keywords
Equisetin Targets Intracellular Staphylococcus aureus through a Host Acting Strategy
Sign Up to like & getrecommendations! Published in 2022 at "Marine Drugs"
DOI: 10.3390/md20110656
Abstract: Mammalian cells act as reservoirs of internalized bacteria to circumvent extracellular antibacterial compounds, resulting in relapse and reinfection diseases. The intracellular persistence of Staphylococcus aureus renders most traditional antibiotics useless, due to their inadequate subcellular… read more here.
Keywords: staphylococcus aureus; host acting; host; targets intracellular ... See more keywords