Genome-wide CRISPR screening uncovers potential targets and mechanisms of vincristine resistance in DLBCL.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of haematology"
DOI: 10.1111/bjh.18900
Abstract: In this issue, Rovsing et al. employ unbiased genome-wide CRISPR screening and functional cellular assays to investigate the cellular response to vincristine, an important component of the front-line DLBCL treatment R-CHOP. Their findings reveal intriguing… read more here.
Keywords: genome wide; dlbcl; wide crispr; crispr screening ... See more keywords
Repurposing disulfiram as a chemo-therapeutic sensitizer: molecular targets and mechanisms.
Sign Up to like & getrecommendations! Published in 2022 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520621666220415102553
Abstract: Currently, chemo-therapy is still the main strategy for cancer treatment. However, chemo-therapy resistance remains its main challenge. Disulfiram [DSF] is a drug approved by FDA for the treatment of alcohol addiction, but it is later… read more here.
Keywords: therapeutic sensitizer; chemo; molecular targets; targets mechanisms ... See more keywords
Network pharmacology and experimental studies for deciphering the molecular targets and mechanisms of Chaihu Shugan powder in the treatment of functional dyspepsia
Sign Up to like & getrecommendations! Published in 2023 at "Technology and Health Care"
DOI: 10.3233/thc-236039
Abstract: BACKGROUND: Chaihu Shugan powder (CSP) is a prevalent prescription product used in the treatment functional dyspepsia (FD) in China. However, the underlying pharmacological mechanisms involved in the treatment of FD remain unclear. OBJECTIVE: To explore… read more here.
Keywords: targets mechanisms; pharmacology; shugan powder; molecular targets ... See more keywords
Novel Targets and Mechanisms in Antimicrobial Drug Discovery
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DOI: 10.3390/antibiotics10020141
Abstract: The spread of infections resistant to available anti-infective drugs is a serious menace to human health [...]. read more here.
Keywords: mechanisms antimicrobial; antimicrobial drug; novel targets; drug discovery ... See more keywords
Microbial Genomics: Innovative Targets and Mechanisms
Sign Up to like & getrecommendations! Published in 2023 at "Antibiotics"
DOI: 10.3390/antibiotics12020190
Abstract: Multidrug resistance (MDR) has become an increasing threat to global health because bacteria can develop resistance to antibiotics over time. Scientists worldwide are searching for new approaches that go beyond traditional antibiotic discovery and development… read more here.
Keywords: innovative targets; genomics innovative; microbial genomics; targets mechanisms ... See more keywords