Single-cell and bulk transcriptomics of the liver reveals potential targets of NASH with fibrosis
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-98806-y
Abstract: Fibrosis is characterized by the excessive production of collagen and other extracellular matrix (ECM) components and represents a leading cause of morbidity and mortality worldwide. Previous studies of nonalcoholic steatohepatitis (NASH) with fibrosis were largely… read more here.
Keywords: single cell; fibrosis; bulk; nash fibrosis ... See more keywords
Emerging therapeutic targets for NASH: key innovations at the preclinical level
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2020.1728742
Abstract: ABSTRACT Introduction: nonalcoholic steatohepatitis (NASH) is a globally emerging health problem, mainly caused by increasing trends in the prevalence of obesity and metabolic syndrome. Patients with NASH are mainly affected by cardiovascular risk and extrahepatic… read more here.
Keywords: emerging therapeutic; key innovations; therapeutic targets; innovations preclinical ... See more keywords