Metabotropic glutamate receptors as targets for novel anxiolytics
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Pharmacology"
DOI: 10.1016/j.coph.2018.02.004
Abstract: HighlightsPositive correlation between mGlu5 receptor signaling and anxiety‐related symptoms.mGlu5 receptor NAMs reduce OCD‐like symptoms in preclinical studies.Activation of mGlu4 receptors abolishes chronic pain‐induced anxiety in mice.Therapeutic potential of mGlu receptor modulation for anxiety disorders. &NA;… read more here.
Keywords: targets novel; metabotropic glutamate; anxiety disorders; mglu ... See more keywords
Glial Cells and Itch: Possible Targets for Novel Antipruritic Therapies.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00638
Abstract: Glial cells, which are the non-neuronal cells of the nervous system, play essential roles in brain development, homeostasis, and diseases. Glial cells have attracted attention because of their active involvement in many neurological disorders. In… read more here.
Keywords: cells itch; itch possible; novel antipruritic; targets novel ... See more keywords
EDITORIAL; GPCR Drug Discovery: Emerging Targets, Novel Approaches and Future Trends.
Sign Up to like & getrecommendations! Published in 2019 at "Current topics in medicinal chemistry"
DOI: 10.2174/156802661916190828093500
Abstract: read more here.
Keywords: targets novel; gpcr drug; editorial gpcr; drug discovery ... See more keywords
Cytokines as Targets of Novel Therapies for Graves’ Ophthalmopathy
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2021.654473
Abstract: Graves’ disease (GD) is an organ-specific autoimmune disorder of the thyroid, which is characterized by circulating TSH-receptor (TSH-R) stimulating antibodies (TSAb), leading to hyperthyroidism. Graves’ ophthalmopathy (GO) is one of GD extra-thyroidal manifestations associated with… read more here.
Keywords: targets novel; graves ophthalmopathy; autoimmune; therapies graves ... See more keywords
Progress of anti-tuberculosis drug targets and novel therapeutic strategies
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2025.1637254
Abstract: Tuberculosis, a chronic infectious disease caused by Mycobacterium tuberculosis complex, has re-emerged as the leading cause of death worldwide as a single infectious agent. The increasing prevalence of multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis poses… read more here.
Keywords: therapeutic strategies; drug targets; targets novel; tuberculosis ... See more keywords
Editorial: Identification of therapeutic targets and novel biomarkers in prostate cancer volume II
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1163235
Abstract: COPYRIGHT © 2023 Sharad and Srinivasan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the… read more here.
Keywords: novel biomarkers; biomarkers prostate; editorial identification; identification therapeutic ... See more keywords
Molecular Targets for Novel Therapeutics in Pediatric Fusion-Positive Non-CNS Solid Tumors
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.747895
Abstract: Chromosomal fusions encoding novel molecular drivers have been identified in several solid tumors, and in recent years the identification of such pathogenetic events in tumor specimens has become clinically actionable. Pediatric sarcomas and other rare… read more here.
Keywords: molecular targets; novel therapeutics; cns; solid tumors ... See more keywords
Conformational Properties and Putative Bioactive Targets for Novel Thiosemicarbazone Derivatives
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27144548
Abstract: The structure assignment and conformational analysis of the thiosemicarbazones, DKI21 and DKI24, were performed through homonuclear and heteronuclear 2D Nuclear Magnetic Resonance (NMR) spectroscopy (2D-COSY, 2D-NOESY, 2D-ROESY, 2D-HSQC, and 2D-HMBC) and quantum mechanics (QM) calculations,… read more here.
Keywords: bioactive targets; properties putative; noesy roesy; targets novel ... See more keywords
Topoisomerases as Targets for Novel Drug Discovery
Sign Up to like & getrecommendations! Published in 2025 at "Pharmaceuticals"
DOI: 10.3390/ph18111693
Abstract: DNA topoisomerases (topo) are essential enzymes that maintain the integrity of the genome by regulating the topological state of DNA during replication, transcription, recombination and repair [...]. read more here.
Keywords: novel drug; topoisomerases targets; targets novel; drug discovery ... See more keywords