Ceramide Synthases Are Attractive Drug Targets for Treating Metabolic Diseases
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2020.00483
Abstract: Ceramide synthases (CerS) are central enzymes required for the de-novo synthesis of ceramides and other sphingolipids. They catalyze the addition of different acyl-chains to a sphingoid base, and thus account for much of the rich… read more here.
Keywords: drug targets; treating metabolic; ceramide synthases; synthases attractive ... See more keywords
Pathological Targets for Treating Temporal Lobe Epilepsy: Discoveries From Microscale to Macroscale
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2021.779558
Abstract: Temporal lobe epilepsy (TLE) is one of the most common and severe types of epilepsy, characterized by intractable, recurrent, and pharmacoresistant seizures. Histopathology of TLE is mostly investigated through observing hippocampal sclerosis (HS) in adults,… read more here.
Keywords: targets treating; temporal lobe; pathological targets; lobe epilepsy ... See more keywords
Thermo-Sensitive TRP Channels: Novel Targets for Treating Chemotherapy-Induced Peripheral Pain
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2017.01040
Abstract: Abnormal Ca2+ channel physiology, expression levels, and hypersensitivity to heat have been implicated in several pain states following treatment with chemotherapeutic agents. As members of the Ca2+ permeable transient receptor potential (TRP), five of the… read more here.
Keywords: trp channels; trpa1 trpm8; novel targets; physiology ... See more keywords