Serotonergic targets for the treatment of l-DOPA-induced dyskinesia
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-017-1837-1
Abstract: Dopamine (DA) replacement therapy with l-3,4-dihydroxyphenylalanine (l-DOPA) continues to be the gold-standard treatment for Parkinson’s disease (PD). Despite clear symptomatic benefit, long-term l-DOPA use often results in the development of l-DOPA-induced dyskinesia (LID), significantly reducing… read more here.
Keywords: targets treatment; treatment; serotonergic targets; dopa ... See more keywords
PARPs and PAR as novel pharmacological targets for the treatment of stress granule-associated disorders.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.05.019
Abstract: Among the post-translational modifications, ADP-ribosylation has been for long time the least integrated in the scheme of the structural protein modifications affecting physiological functions. In spite of the original findings on bacterial-dependent ADP-ribosylation catalysed by… read more here.
Keywords: novel pharmacological; targets treatment; stress; stress granule ... See more keywords
Progeria: a perspective on potential drug targets and treatment strategies
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2022.2078699
Abstract: Hutchinson-Gilford progeria syndrome (HGPS) is an ultra-rare genetic disease characterized by premature aging and death at an average age of 14.6 years. Most HGPS patients are heterozygous carriers of a de novo synonymous mutation in… read more here.
Keywords: treatment strategies; perspective potential; potential drug; targets treatment ... See more keywords
Enzyme Inhibitors as the Attractive Targets for the Treatment of Various Diseases.
Sign Up to like & getrecommendations! Published in 2019 at "Current medicinal chemistry"
DOI: 10.2174/092986732618190821115641
Abstract: read more here.
Keywords: targets treatment; various diseases; treatment various; enzyme inhibitors ... See more keywords
Novel Therapeutic Approaches And Targets For Treatment Of Chronic Urticaria: New Insights And Promising Targets For A Challenging Disease.
Sign Up to like & getrecommendations! Published in 2020 at "Current pharmaceutical biotechnology"
DOI: 10.2174/1389201021666200630140137
Abstract: BACKGROUND Chronic spontaneous urticaria (CSU) is a disease characterized by the onset of wheals and/or angioedema over 6 weeks. The pathophysiology for CSU is very complex, involving mast cells and basophils with a multitude of… read more here.
Keywords: targets treatment; urticaria new; treatment; disease ... See more keywords
Melanocortin receptors: emerging targets for the treatment of pigmentation, inflammation, stress, weight disorders and sexual dysfunction.
Sign Up to like & getrecommendations! Published in 2022 at "Current drug targets"
DOI: 10.2174/1389450124666221108143006
Abstract: Melanocortins are tiny protein molecules formed by the post-translational cleavage of proopiomelanocortin. These are bioactive peptides that are responsible for human and lower animal pigmentation patterns, energy homeostasis, and sexual function modulation. These peptides regulate… read more here.
Keywords: melanocortin receptors; targets treatment; receptors emerging; pigmentation ... See more keywords
Immune Mechanisms and Related Targets for the Treatment of Fibrosis in Various Organs.
Sign Up to like & getrecommendations! Published in 2022 at "Current molecular medicine"
DOI: 10.2174/1566524022666220114122839
Abstract: Inflammation and fibrosis are two inter-related disease pathologies with several overlapping components. Three specific cell types, macrophages, T helper cells and myofibroblasts, each play important roles in regulating both processes. Following tissue injury, an inflammatory… read more here.
Keywords: immune mechanisms; related targets; inflammatory cells; mechanisms related ... See more keywords
Promising Therapeutic Targets for Treatment of Rheumatoid Arthritis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.686155
Abstract: Rheumatoid arthritis (RA) is a systemic poly-articular chronic autoimmune joint disease that mainly damages the hands and feet, which affects 0.5% to 1.0% of the population worldwide. With the sustained development of disease-modifying antirheumatic drugs… read more here.
Keywords: targets treatment; therapeutic targets; treatment rheumatoid; rheumatoid arthritis ... See more keywords