Imaging of Transmembrane AMPA Receptor Regulatory Proteins by Positron Emission Tomography.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00377
Abstract: The transmembrane α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid (AMPA) receptor regulatory protein γ-8 (TARP γ-8) constitutes an auxiliary subunit of AMPA receptors, which mediates various brain functions including learning and memory. TARP γ-8 has emerged as a promising therapeutic… read more here.
Keywords: positron emission; ampa receptor; transmembrane; tarp ... See more keywords
Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28404-7
Abstract: AMPA-type glutamate receptors (AMPARs) mediate rapid signal transmission at excitatory synapses in the brain. Glutamate binding to the receptor’s ligand-binding domains (LBDs) leads to ion channel activation and desensitization. Gating kinetics shape synaptic transmission and… read more here.
Keywords: ampa; glua1 ampa; tarp; ampa receptor ... See more keywords
Fluorescence-Reported Allelic Exchange Mutagenesis-Mediated Gene Deletion Indicates a Requirement for Chlamydia trachomatis Tarp during In Vivo Infectivity and Reveals a Specific Role for the C Terminus during Cellular Invasion
Sign Up to like & getrecommendations! Published in 2020 at "Infection and Immunity"
DOI: 10.1128/iai.00841-19
Abstract: The translocated actin recruiting phosphoprotein (Tarp) is a multidomain type III secreted effector used by Chlamydia trachomatis. In aggregate, existing data suggest a role of this effector in initiating new infections. As new genetic tools… read more here.
Keywords: role; tarp; invasion; chlamydia trachomatis ... See more keywords
The Chlamydia trachomatis Early Effector Tarp Outcompetes Fascin in Forming F-Actin Bundles In Vivo
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.811407
Abstract: The intracellular pathogen Chlamydia trachomatis secretes multiple early effectors into the host cell to promote invasion. A key early effector during host cell entry, Tarp (translocated actin-recruiting phosphoprotein) is comprised of multiple protein domains known… read more here.
Keywords: actin bundles; actin; chlamydia trachomatis; tarp ... See more keywords
A TARP Syndrome Phenotype Is Associated with a Novel Splicing Variant in RBM10
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13112154
Abstract: TARP syndrome (Talipes equinovarus, Atrial septal defect, Robin sequence, and Persistence of the left superior vena cava) is a rare genetic condition, caused by developmental defects during embryogenesis. The phenotypic spectrum of TARP shows high… read more here.
Keywords: tarp syndrome; rbm10; tarp; phenotype associated ... See more keywords