Discovery of TAS2R14 Agonists from Platycodon grandiflorum Using Virtual Screening and Affinity Screening Based on a Novel TAS2R14-Functionalized HEMT Sensor Combined with UPLC-MS Analysis.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.8b04455
Abstract: TAS2R14 is of great potential as a therapeutic target against asthma, and the discovery of TAS2R14 agonists can be very valuable for treating this disease. Herein, we developed a strategy using virtual screening and affinity… read more here.
Keywords: virtual screening; tas2r14; tas2r14 agonists; discovery tas2r14 ... See more keywords
Functionally expressed bitter taste receptor TAS2R14 in human epidermal keratinocytes serves as a chemosensory receptor
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Dermatology"
DOI: 10.1111/exd.14250
Abstract: Traditionally, it is theorized that skin sensation is initiated when cutaneous sensory afferents and Merkel cells receive sensory stimuli, while epidermal keratinocytes were deemed to have no role. However, mounting evidence has shown that keratinocytes… read more here.
Keywords: tas2r14; epidermal keratinocytes; chemosensory receptor; serves chemosensory ... See more keywords
A Par3/LIM Kinase/Cofilin Pathway Mediates Human Airway Smooth Muscle Relaxation by TAS2R14.
Sign Up to like & getrecommendations! Published in 2023 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2022-0303oc
Abstract: Bitter taste receptors (TAS2Rs) are G protein-coupled receptors expressed on human airway smooth muscle (HASM) cells; when activated by receptor agonists they evoke marked airway relaxation. In both taste and HASM cells, TAS2Rs activate a… read more here.
Keywords: lim kinase; tas2r14; relaxation; human airway ... See more keywords
New values of a type 2 taste receptor TAS2R14 in thyroid cancer
Sign Up to like & getrecommendations! Published in 2022 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.3724/abbs.2022026
Abstract: Recognition of bitter substances is mediated by type 2 taste receptors (TAS2Rs) family which consists of over 20 members. Tra-ditionally, TAS2Rs are thought to be specifically expressed in the tongue. Recent studies on TAS2R member… read more here.
Keywords: tas2r14 also; taste; values type; tas2r14 ... See more keywords