The K2P‐channel TASK1 affects Oligodendroglial differentiation but not myelin restoration
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23577
Abstract: In multiple sclerosis, demyelination occurs as a consequence of chronic autoimmunity in the central nervous system causing progressive neurological impairment in patients. After a demyelinating event, new myelin sheaths are formed by adult oligodendroglial progenitor… read more here.
Keywords: remyelination; task1; k2p channel; differentiation ... See more keywords
Lysophosphatidic Acid and Several Neurotransmitters Converge on Rho-Kinase 2 Signaling to Manage Motoneuron Excitability
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2021.788039
Abstract: Intrinsic membrane excitability (IME) sets up neuronal responsiveness to synaptic drive. Several neurotransmitters and neuromodulators, acting through G-protein-coupled receptors (GPCRs), fine-tune motoneuron (MN) IME by modulating background K+ channels TASK1. However, intracellular partners linking GPCRs… read more here.
Keywords: excitability; several neurotransmitters; task1; rock2 ... See more keywords