Establishment of a monoclonal antibody PMab-233 for immunohistochemical analysis against Tasmanian devil podoplanin
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2019.100631
Abstract: Monoclonal antibodies (mAbs) against not only human, mouse, and rat but also rabbit, dog, cat, bovine, pig, and horse podoplanins (PDPNs) have been established in our previous studies. PDPN is used as a lymphatic endothelial… read more here.
Keywords: tasmanian devil; immunohistochemical analysis; taspdpn; pmab 233 ... See more keywords
The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Cell"
DOI: 10.1016/j.ccell.2018.11.018
Abstract: Summary The marsupial Tasmanian devil (Sarcophilus harrisii) faces extinction due to transmissible devil facial tumor disease (DFTD). To unveil the molecular underpinnings of this transmissible cancer, we combined pharmacological screens with an integrated systems-biology characterization.… read more here.
Keywords: devil facial; stat3; erbb stat3; tasmanian devil ... See more keywords
Nematodes from the Tasmanian devil (Sarcophilus harrisii (Boitard)), with the description of Sarcophiloxyuris longus n. gen. and n. sp. (Oxyuridae)
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Helminthology"
DOI: 10.1017/s0022149x21000298
Abstract: Abstract The Tasmanian devil (Sarcophilus harrisii (Boitard)) is an endangered carnivorous marsupial, limited to the islands of Tasmania in southern Australia. The parasites of the Tasmanian devil are understudied. This study aimed to increase the… read more here.
Keywords: devil; tasmanian devil; harrisii boitard; devil sarcophilus ... See more keywords
Induced Pluripotent Stem Cells from a Marsupial, the Tasmanian Devil (Sarcophilus harrisii): Insight into the Evolution of Mammalian Pluripotency.
Sign Up to like & getrecommendations! Published in 2018 at "Stem cells and development"
DOI: 10.1089/scd.2017.0224
Abstract: We demonstrate the generation of Tasmanian devil (Sarcophilus harrisii) induced pluripotent stem cells (DeviPSCs) from dermal fibroblasts by lentiviral delivery of human transcription factors. DeviPSCs display characteristic pluripotent stem cell colony morphology, with individual cells… read more here.
Keywords: sarcophilus harrisii; tasmanian devil; pluripotent stem; stem ... See more keywords
Two Decades of the Impact of Tasmanian Devil Facial Tumor Disease.
Sign Up to like & getrecommendations! Published in 2018 at "Integrative and comparative biology"
DOI: 10.1093/icb/icy118
Abstract: The Tasmanian devil, a marsupial carnivore, has been restricted to the island state of Tasmania since its extinction on the Australian mainland about 3000 years ago. In the past two decades, this species has experienced severe… read more here.
Keywords: disease; tasmanian devil; biology; two decades ... See more keywords
Class II transactivator induces expression of MHC-I and MHC-II in transmissible Tasmanian devil facial tumours
Sign Up to like & getrecommendations! Published in 2022 at "Open Biology"
DOI: 10.1098/rsob.220208
Abstract: MHC-I and MHC-II molecules are critical components of antigen presentation and T cell immunity to pathogens and cancer. The two monoclonal transmissible devil facial tumours (DFT1, DFT2) exploit MHC-I pathways to overcome immunological anti-tumour and… read more here.
Keywords: mhc; devil facial; facial tumours; mhc mhc ... See more keywords
Transmissible cancer influences immune gene expression in an endangered marsupial, the Tasmanian devil (Sarcophilus harrisii)
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Ecology"
DOI: 10.1111/mec.16408
Abstract: Understanding the effects of wildlife diseases on populations requires insight into local environmental conditions, host defence mechanisms, host life‐history trade‐offs, pathogen population dynamics, and their interactions. The survival of Tasmanian devils (Sarcophilus harrisii) is challenged… read more here.
Keywords: immune gene; expression; sarcophilus harrisii; cancer ... See more keywords
Transcriptome and proteome profiling reveals stress-induced expression signatures of imiquimod-treated Tasmanian devil facial tumor disease (DFTD) cells
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.24634
Abstract: As a topical cancer immunotherapy, the toll-like receptor 7 ligand imiquimod activates tumor regression via stimulation of immune cell infiltration and cytotoxic responses. Imiquimod also exerts direct pro-apoptotic effects on tumor cells in vitro, but… read more here.
Keywords: cell; tasmanian devil; expression; imiquimod ... See more keywords
Cathelicidin-3 Associated With Serum Extracellular Vesicles Enables Early Diagnosis of a Transmissible Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.858423
Abstract: The identification of practical early diagnostic biomarkers is a cornerstone of improved prevention and treatment of cancers. Such a case is devil facial tumor disease (DFTD), a highly lethal transmissible cancer afflicting virtually an entire… read more here.
Keywords: transmissible cancer; diagnosis; cancer; tasmanian devil ... See more keywords
Between the Devil and the Deep Blue Sea: Non-Coding RNAs Associated with Transmissible Cancers in Tasmanian Devil, Domestic Dog and Bivalves
Sign Up to like & getrecommendations! Published in 2021 at "Non-Coding RNA"
DOI: 10.3390/ncrna7040072
Abstract: Currently there are nine known examples of transmissible cancers in nature. They have been observed in domestic dog, Tasmanian devil, and six bivalve species. These tumours can overcome host immune defences and spread to other… read more here.
Keywords: transmissible cancers; tasmanian devil; domestic dog; non coding ... See more keywords