T2R bitter taste receptors regulate apoptosis and may be associated with survival in head and neck squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13131
Abstract: Better management of head and neck squamous cell carcinomas (HNSCCs) requires a clearer understanding of tumor biology and disease risk. Bitter taste receptors (T2Rs) have been studied in several cancers, including thyroid, salivary, and GI,… read more here.
Keywords: neck squamous; taste receptors; squamous cell; bitter taste ... See more keywords
Bitter taste receptors are expressed in human epithelial ovarian and prostate cancers cells and noscapine stimulation impacts cell survival
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-018-3464-z
Abstract: Bitter taste receptors (Tas2Rs) are a subfamily of G-protein coupled receptors expressed not only in the oral cavity but also in several extra-oral tissues and disease states. Several natural bitter compounds from plants, such as… read more here.
Keywords: epithelial ovarian; taste receptors; receptors expressed; ovarian prostate ... See more keywords
The druggability of bitter taste receptors for the treatment of neurodegenerative disorders.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2022.114915
Abstract: The delivery of therapeutic drugs to the brain remains a major pharmacology challenge. A complex system of chemical surveillance to protect the brain from endogenous and exogenous toxicants at brain barriers hinders the uptake of… read more here.
Keywords: bitter taste; treatment; pharmacology; brain ... See more keywords
Hen protein-derived peptides as the blockers of human bitter taste receptors T2R4, T2R7 and T2R14.
Sign Up to like & getrecommendations! Published in 2019 at "Food chemistry"
DOI: 10.1016/j.foodchem.2019.01.059
Abstract: Bitter sensation is mediated by various bitter taste receptors (T2Rs), thus T2R antagonists are actively explored. Our objective was to look for novel T2R blockers in hen protein hydrolysate (HPH). We screened the least bitter… read more here.
Keywords: t2r4 t2r7; taste receptors; hen protein; t2r7 t2r14 ... See more keywords
Multi-scale simulations of membrane proteins: The case of bitter taste receptors
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Science: Advanced Materials and Devices"
DOI: 10.1016/j.jsamd.2017.03.001
Abstract: Abstract Human bitter taste receptors (hTAS2Rs) are the second largest group of chemosensory G-protein coupled receptors (25 members). hTAS2Rs are expressed in many tissues (e.g. tongue, gastrointestinal tract, respiratory system, brain, etc.), performing a variety… read more here.
Keywords: taste; taste receptors; case; site ... See more keywords
Therapeutic potential of targeting intestinal bitter taste receptors in diabetes associated with dyslipidemia.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.105693
Abstract: Intestinal release of incretin hormones after food intake promotes glucose-dependent insulin secretion and regulates glucose homeostasis. The impaired incretin effects observed in the pathophysiologic abnormality of type 2 diabetes have triggered the pharmacological development of… read more here.
Keywords: taste; bitter taste; glp secretion; taste receptors ... See more keywords
Activation Spectra of Human Bitter Taste Receptors Stimulated with Cyclolinopeptides Corresponding to Fresh and Aged Linseed Oil
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Agricultural and Food Chemistry"
DOI: 10.1021/acs.jafc.2c00976
Abstract: Linseed oil is rich in unsaturated fatty acids, and its increased consumption could aid in health-promoting nutrition. However, rapid oxidation of linseed oil and concomitant development of bitterness impair consumers’ acceptance. Previous research revealed that… read more here.
Keywords: oil; human bitter; bitterness; taste receptors ... See more keywords
Human Bitter Taste Receptors Are Activated by Different Classes of Polyphenols.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.8b03569
Abstract: Polyphenols may contribute directly to plant-based foodstuffs flavor, in particular to astringency and bitterness. In this work, the bitterness of a small library of polyphenols from different classes [procyanidin dimers type B, ellagitannins (punicalagin, castalagin,… read more here.
Keywords: taste; taste receptors; different classes; receptors activated ... See more keywords
Characterization of the Binding Sites for Bacterial Acyl Homoserine Lactones (AHLs) on Human Bitter Taste Receptors (T2Rs).
Sign Up to like & getrecommendations! Published in 2018 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.8b00094
Abstract: The 25 bitter taste receptors (T2Rs) in humans are novel players in mediating host-pathogen responses in the airways and innate immunity. The chemosensory T2Rs are expressed in different extraoral tissues and perform diverse pathophysiological roles… read more here.
Keywords: taste; taste receptors; receptors t2rs; t2rs ... See more keywords
Sensation of dietary nutrients by gut taste receptors and its mechanisms.
Sign Up to like & getrecommendations! Published in 2022 at "Critical reviews in food science and nutrition"
DOI: 10.1080/10408398.2021.2021388
Abstract: Nutrients sensing is crucial for fundamental metabolism and physiological functions, and it is also an essential component for maintaining body homeostasis. Traditionally, basic taste receptors exist in oral cavity to sense sour, sweet, bitter, umami,… read more here.
Keywords: sensation dietary; taste; taste receptors; dietary nutrients ... See more keywords
A comprehensive review of the metabolism of citrus flavonoids and their binding to bitter taste receptors.
Sign Up to like & getrecommendations! Published in 2023 at "Comprehensive reviews in food science and food safety"
DOI: 10.1111/1541-4337.13129
Abstract: Citrus is an important source of flavonoids in our daily diet. Citrus flavonoids have antioxidant, anticancer, anti-inflammatory, and cardiovascular disease prevention functions. Studies have shown that some pharmaceutical values of flavonoids may be related to… read more here.
Keywords: citrus flavonoids; taste receptors; binding bitter; citrus ... See more keywords