Guaiazulene derivative 1,2,3,4-tetrahydroazuleno[1,2-b] tropone (TAT) reduces the production of ATP by inhibiting electron transfer complex II.
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DOI: 10.1002/2211-5463.13215
Abstract: Molecularly targeted therapy has been employed for treatment of various types of cancers. However, cancer cells often acquire resistance to molecularly targeted drugs that inhibit specific molecular abnormalities, such as constitutive activation of kinases. Even… read more here.
Keywords: production; cancer cells; cancer; tropone tat ... See more keywords
Conditional expression of HIV-1 Tat in the mouse alters the onset and progression of tonic, inflammatory, and neuropathic hypersensitivity in a sex-dependent manner.
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DOI: 10.1002/ejp.1618
Abstract: At least one third of HIV-1-afflicted individuals experience peripheral neuropathy. Although the underlying mechanisms are not known, they may involve neurotoxic HIV-1 proteins. We assessed the influence of the neurotoxic HIV-1 regulatory protein, Tat, on… read more here.
Keywords: hiv; sex; hiv tat; hypersensitivity ... See more keywords
HIV Tat causes synapse loss in a mouse model of HIV‐associated neurocognitive disorder that is independent of the classical complement cascade component C1q
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DOI: 10.1002/glia.23511
Abstract: Microglial activation, increased proinflammatory cytokine production, and a reduction in synaptic density are key pathological features associated with HIV‐associated neurocognitive disorders (HAND). Even with combination antiretroviral therapy (cART), more than 50% of HIV‐positive individuals experience… read more here.
Keywords: hiv; complement; associated neurocognitive; tat ... See more keywords
Transanastomotic tubes reduce the cost of nutritional support in neonates with congenital duodenal obstruction
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DOI: 10.1007/s00383-018-4411-5
Abstract: PurposeTo determine the impact of intra-operative Trans-anastomotic Tube (TAT) placement on the cost of post-operative nutrition in infants with congenital duodenal obstruction (CDO).MethodsA retrospective analysis of patients undergoing corrective surgery for CDO, with birth-weight over… read more here.
Keywords: transanastomotic tubes; congenital duodenal; duodenal obstruction; cost ... See more keywords
Genetic variation and function of the HIV-1 Tat protein
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DOI: 10.1007/s00430-019-00583-z
Abstract: Human immunodeficiency virus type 1 (HIV-1) encodes a transactivator of transcription (Tat) protein, which has several functions that promote viral replication, pathogenesis, and disease. Amino acid variation within Tat has been observed to alter the… read more here.
Keywords: genetic variation; hiv; tat protein; tat ... See more keywords
Design of Tat-Activated Cdk9 Inhibitor
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DOI: 10.1007/s10989-018-9730-9
Abstract: Virus mutates quickly and develops drug resistance over time if targeted directly. A possible alternative for drug design is to target cellular proteins that the virus needs. To be viable, the drug ought to inhibit… read more here.
Keywords: cdk9 cyclin; cdk9; drug; tat ... See more keywords
HIV-1 Tat-Induced Astrocytic Extracellular Vesicle miR-7 Impairs Synaptic Architecture
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DOI: 10.1007/s11481-019-09869-8
Abstract: Although combination antiretroviral therapy (cART) has improved the health of millions of those living with HIV-1 (Human Immunodeficiency Virus, Type 1), the penetration into the central nervous system (CNS) of many such therapies is limited,… read more here.
Keywords: extracellular vesicle; mir; hiv; hiv tat ... See more keywords
Differential Mechanisms of Inflammation and Endothelial Dysfunction by HIV-1 Subtype-B and Recombinant CRF02_AG Tat Proteins on Human Brain Microvascular Endothelial Cells: Implications for Viral Neuropathogenesis
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DOI: 10.1007/s12035-017-0382-0
Abstract: The recombinant HIV-1 CRF02_AG is prevalent in West-Central Africa but its effects on the blood-brain barrier (BBB) and HIV-associated neurocognitive disorders (HAND) are not known. We analyzed the effects of Tat from HIV-1 subtype-B (Tat.B)… read more here.
Keywords: hiv; hiv subtype; brain; tat ... See more keywords
Doxycycline-inducible and astrocyte-specific HIV-1 Tat transgenic mice (iTat) as an HIV/neuroAIDS model
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DOI: 10.1007/s13365-017-0598-9
Abstract: HIV-1 Tat is known to be neurotoxic and important for HIV/neuroAIDS pathogenesis. However, the overwhelming majority of the studies involved use of recombinant Tat protein. To understand the contributions of Tat protein to HIV/neuroAIDS and… read more here.
Keywords: astrocyte; hiv; hiv neuroaids; mice ... See more keywords
HIV-1 Tat and opioids act independently to limit antiretroviral brain concentrations and reduce blood–brain barrier integrity
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DOI: 10.1007/s13365-019-00757-8
Abstract: Poor antiretroviral penetration may contribute to human immunodeficiency virus (HIV) persistence within the brain and to neurocognitive deficits in opiate abusers. To investigate this problem, HIV-1 Tat protein and morphine effects on blood–brain barrier (BBB)… read more here.
Keywords: blood brain; morphine; hiv tat; brain ... See more keywords
87 Redeployment of Potentially Furloughed Staff During a Pandemic Improves Emergency Department Operations
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DOI: 10.1016/j.annemergmed.2021.07.089
Abstract: Study Objectives: The COVID-19 pandemic resulted in a change in demand for health care employees. While workload increased for many front-line providers, other health care workers were furloughed. Here, we describe the redeployment of occupational… read more here.
Keywords: health care; staff; emergency; care ... See more keywords