Hydrocarbon staple constructing highly efficient α-helix cell-penetrating peptides for intracellular cargo delivery.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc06312f
Abstract: The effects of all-hydrocarbon cross-linking on the cell-penetrating properties of Tat were systematically investigated. These stapled cell-penetrating peptides were designed to exhibit a cationic secondary amphipathic profile. We found that the hydrophobicity and helical conformation… read more here.
Keywords: cell penetrating; tat peptides; stapled tat; hydrocarbon staple ... See more keywords
Regulation of in vivo behavior of TAT-modified liposome by associated protein corona and avidity to tumor cells
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s170274
Abstract: Introduction PEGylated liposomes are widely used and studied as carriers for chemotherapeutics. While pharmacokinetics of the encapsulated drug is drastically altered resulting in favorable circulation time, improved tumor accumulation, and better manageable or reduced side… read more here.
Keywords: tumor; tumor cells; tat modified; protein corona ... See more keywords