Genetic variation and function of the HIV-1 Tat protein
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DOI: 10.1007/s00430-019-00583-z
Abstract: Human immunodeficiency virus type 1 (HIV-1) encodes a transactivator of transcription (Tat) protein, which has several functions that promote viral replication, pathogenesis, and disease. Amino acid variation within Tat has been observed to alter the… read more here.
Keywords: genetic variation; hiv; tat protein; tat ... See more keywords
The HIV-1 Tat Protein Enhances Splicing at the Major Splice Donor Site
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DOI: 10.1128/jvi.01855-17
Abstract: ABSTRACT Transcription of the HIV-1 proviral DNA and subsequent processing of the primary transcript results in the production of a large set of unspliced and differentially spliced viral RNAs. The major splice donor site (5′ss)… read more here.
Keywords: transcription; production; tat protein; site ... See more keywords
Protective effects of Tat-DJ-1 protein against streptozotocin-induced diabetes in a mice model
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DOI: 10.5483/bmbrep.2018.51.7.101
Abstract: A major feature of type 1 diabetes mellitus (T1DM) is hyperglycemia and dysfunction of pancreatic β-cells. In a previous study, we have shown that Tat-DJ-1 protein inhibits pancreatic RINm5F β-cell death caused by oxidative stress.… read more here.
Keywords: protein; tat protein; protein streptozotocin; effects tat ... See more keywords