Comparing Plasma Phospho Tau, Total Tau, and Phospho Tau–Total Tau Ratio as Acute and Chronic Traumatic Brain Injury Biomarkers
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Neurology"
DOI: 10.1001/jamaneurol.2017.0655
Abstract: Importance Annually in the United States, at least 3.5 million people seek medical attention for traumatic brain injury (TBI). The development of therapies for TBI is limited by the absence of diagnostic and prognostic biomarkers.… read more here.
Keywords: tau; tau tau; tau total; tbi ... See more keywords
Association of Apolipoprotein E ε4 With Medial Temporal Tau Independent of Amyloid-β.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2019.4421
Abstract: Importance Apolipoprotein E ε4 (APOEε4) is the single most important genetic risk factor for Alzheimer disease. While APOEε4 is associated with increased amyloid-β burden, its association with cerebral tau pathology has been controversial. Objective To… read more here.
Keywords: pet; tau; amyloid; alzheimer disease ... See more keywords
Assessment of Demographic, Genetic, and Imaging Variables Associated With Brain Resilience and Cognitive Resilience to Pathological Tau in Patients With Alzheimer Disease
Sign Up to like & getrecommendations! Published in 2020 at "JAMA Neurology"
DOI: 10.1001/jamaneurol.2019.5154
Abstract: This cross-sectional, longitudinal study of amyloid-β–positive individuals with mild cognitive impairment or Alzheimer disease dementia examines the factors associated with interindividual differences in brain and cognitive resilience to tau positron emission tomography load and to… read more here.
Keywords: tau; alzheimer disease; resilience; cognitive resilience ... See more keywords
Association of Elevated Amyloid and Tau Positron Emission Tomography Signal With Near-Term Development of Alzheimer Disease Symptoms in Older Adults Without Cognitive Impairment.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2022.2379
Abstract: Importance National Institute on Aging-Alzheimer's Association (NIA-AA) workgroups have proposed biological research criteria intended to identify individuals with preclinical Alzheimer disease (AD). Objective To assess the clinical value of these biological criteria to identify older… read more here.
Keywords: near term; tau; without cognitive; alzheimer disease ... See more keywords
Alzheimer Disease Blood Biomarkers in Patients With Out-of-Hospital Cardiac Arrest
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Neurology"
DOI: 10.1001/jamaneurol.2023.0050
Abstract: Key Points Question Are Alzheimer disease blood biomarkers altered in patients with hypoxic-ischemic injury after cardiac arrest? Findings In this case-control study, blood phosphorylated tau (p-tau) levels were significantly elevated 24 hours after cardiac arrest… read more here.
Keywords: blood; alzheimer disease; cardiac arrest; tau ... See more keywords
Interaction kinetics reveal distinct properties of conformational ensembles of three‐repeat and four‐repeat tau proteins
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14339
Abstract: Tau protein is an intrinsically disordered protein. Its physiological state is best described as a conformational ensemble (CE) of metastable structures interconverting on the local and molecular scale. The monoclonal antibody DC39C recognizes a linear… read more here.
Keywords: tau proteins; tau; three repeat; interaction kinetics ... See more keywords
“Drug‐Carrier” Synergy Therapy for Amyloid‐β Clearance and Inhibition of Tau Phosphorylation via Biomimetic Lipid Nanocomposite Assembly
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202106072
Abstract: Amyloid‐β (Aβ) toxicity is considered to be companioned by Tau phosphorylation in Alzheimer's disease (AD). The clinical AD therapy is usually subjected to low blood‐brain barrier (BBB) penetration and complex interaction mechanisms between Aβ and… read more here.
Keywords: tau; synergy therapy; therapy; synergy ... See more keywords
Icaritin and icariin reduce p-Tau levels in a cell model of Alzheimer's disease by downregulating glycogen synthase kinase 3β.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2114
Abstract: AIMS This study aimed to explore the neuroprotective effect of icariin/icaritin (ICA/ICT) and the role of ICA/ICT in the treatment of Alzheimer's disease (AD). METHODS ICA and ICT were used to treat okadaic acid (OA)-induced… read more here.
Keywords: glycogen synthase; tau; ica ict; alzheimer disease ... See more keywords
Yeast surface display of full‐length human microtubule‐associated protein tau
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology Progress"
DOI: 10.1002/btpr.2920
Abstract: Microtubule‐associated protein tau is an intrinsically disordered, highly soluble protein found primarily in neurons. Under normal conditions, tau regulates the stability of axonal microtubules and intracellular vesicle transport. However, in patients of neurodegeneration such as… read more here.
Keywords: protein; associated protein; tau; microtubule associated ... See more keywords
Direct Observation of the Self‐Aggregation of R3R4 Bi‐repeat of Tau Protein
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DOI: 10.1002/cbic.202100013
Abstract: Abstract: Different cryo‐EM derived atomic models of in vivo tau filaments from patients with tauopathies consisted of R3 and R4 repeats of the microtubule‐binding domain. In comparison, only the R3 repeat forms the core of the… read more here.
Keywords: aggregation; tau; self aggregation; repeat ... See more keywords
Moderators and predictors of treatment outcome in transdiagnostic group cognitive-behavioral therapy for primary care patients with emotional disorders.
Sign Up to like & getrecommendations! Published in 2021 at "Depression and anxiety"
DOI: 10.1002/da.23164
Abstract: OBJECTIVE Transdiagnostic group cognitive behavior therapy (TD-GCBT) has shown to be efficacious in the treatment of emotional disorders in primary care. However, little is known about possible moderators or predictors of treatment outcome. We aimed… read more here.
Keywords: tau; primary care; treatment; emotional disorders ... See more keywords