Comparing Plasma Phospho Tau, Total Tau, and Phospho Tau–Total Tau Ratio as Acute and Chronic Traumatic Brain Injury Biomarkers
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Neurology"
DOI: 10.1001/jamaneurol.2017.0655
Abstract: Importance Annually in the United States, at least 3.5 million people seek medical attention for traumatic brain injury (TBI). The development of therapies for TBI is limited by the absence of diagnostic and prognostic biomarkers.… read more here.
Keywords: tau; tau tau; tau total; tbi ... See more keywords
Association of Apolipoprotein E ε4 With Medial Temporal Tau Independent of Amyloid-β.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2019.4421
Abstract: Importance Apolipoprotein E ε4 (APOEε4) is the single most important genetic risk factor for Alzheimer disease. While APOEε4 is associated with increased amyloid-β burden, its association with cerebral tau pathology has been controversial. Objective To… read more here.
Keywords: pet; tau; amyloid; alzheimer disease ... See more keywords
Assessment of Demographic, Genetic, and Imaging Variables Associated With Brain Resilience and Cognitive Resilience to Pathological Tau in Patients With Alzheimer Disease
Sign Up to like & getrecommendations! Published in 2020 at "JAMA Neurology"
DOI: 10.1001/jamaneurol.2019.5154
Abstract: This cross-sectional, longitudinal study of amyloid-β–positive individuals with mild cognitive impairment or Alzheimer disease dementia examines the factors associated with interindividual differences in brain and cognitive resilience to tau positron emission tomography load and to… read more here.
Keywords: tau; alzheimer disease; resilience; cognitive resilience ... See more keywords
Association of Elevated Amyloid and Tau Positron Emission Tomography Signal With Near-Term Development of Alzheimer Disease Symptoms in Older Adults Without Cognitive Impairment.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2022.2379
Abstract: Importance National Institute on Aging-Alzheimer's Association (NIA-AA) workgroups have proposed biological research criteria intended to identify individuals with preclinical Alzheimer disease (AD). Objective To assess the clinical value of these biological criteria to identify older… read more here.
Keywords: near term; tau; without cognitive; alzheimer disease ... See more keywords
Alzheimer Disease Blood Biomarkers in Patients With Out-of-Hospital Cardiac Arrest
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Neurology"
DOI: 10.1001/jamaneurol.2023.0050
Abstract: Key Points Question Are Alzheimer disease blood biomarkers altered in patients with hypoxic-ischemic injury after cardiac arrest? Findings In this case-control study, blood phosphorylated tau (p-tau) levels were significantly elevated 24 hours after cardiac arrest… read more here.
Keywords: blood; alzheimer disease; cardiac arrest; tau ... See more keywords
Sex Differences in Longitudinal Tau-PET in Preclinical Alzheimer Disease: A Meta-Analysis.
Sign Up to like & getrecommendations! Published in 2025 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2025.0013
Abstract: Importance Alzheimer disease (AD) predominates in females at almost twice the rate relative to males. Mounting evidence in adults without AD indicates that females exhibit higher tau deposition than age-matched males, particularly in the setting… read more here.
Keywords: tau pet; sex differences; tau; sex ... See more keywords
Interaction kinetics reveal distinct properties of conformational ensembles of three‐repeat and four‐repeat tau proteins
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14339
Abstract: Tau protein is an intrinsically disordered protein. Its physiological state is best described as a conformational ensemble (CE) of metastable structures interconverting on the local and molecular scale. The monoclonal antibody DC39C recognizes a linear… read more here.
Keywords: tau proteins; tau; three repeat; interaction kinetics ... See more keywords
Serial amplification of tau filaments using Alzheimer's brain homogenates and C322A or C322S recombinant tau
Sign Up to like & getrecommendations! Published in 2025 at "Febs Letters"
DOI: 10.1002/1873-3468.70141
Abstract: The assembly of tau into amyloid filaments is a defining characteristic of Alzheimer’s disease (AD) and other tauopathies. Cryo-electron microscopy (cryo-EM) showed that specific tau folds characterise different diseases, and that in vitro models often… read more here.
Keywords: alzheimer; brain; 0n3r tau; tau ... See more keywords
“Drug‐Carrier” Synergy Therapy for Amyloid‐β Clearance and Inhibition of Tau Phosphorylation via Biomimetic Lipid Nanocomposite Assembly
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202106072
Abstract: Amyloid‐β (Aβ) toxicity is considered to be companioned by Tau phosphorylation in Alzheimer's disease (AD). The clinical AD therapy is usually subjected to low blood‐brain barrier (BBB) penetration and complex interaction mechanisms between Aβ and… read more here.
Keywords: tau; synergy therapy; therapy; synergy ... See more keywords
Lymphocyte‐Activation Gene 3 Facilitates Pathological Tau Neuron‐to‐Neuron Transmission
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202303775
Abstract: The spread of prion‐like protein aggregates is a common driver of pathogenesis in various neurodegenerative diseases, including Alzheimer's disease (AD) and related Tauopathies. Tau pathologies exhibit a clear progressive spreading pattern that correlates with disease… read more here.
Keywords: pathology; tau; lymphocyte activation; neuron neuron ... See more keywords
Icaritin and icariin reduce p-Tau levels in a cell model of Alzheimer's disease by downregulating glycogen synthase kinase 3β.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2114
Abstract: AIMS This study aimed to explore the neuroprotective effect of icariin/icaritin (ICA/ICT) and the role of ICA/ICT in the treatment of Alzheimer's disease (AD). METHODS ICA and ICT were used to treat okadaic acid (OA)-induced… read more here.
Keywords: glycogen synthase; tau; ica ict; alzheimer disease ... See more keywords