Association of Initial β-Amyloid Levels With Subsequent Flortaucipir Positron Emission Tomography Changes in Persons Without Cognitive Impairment.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2020.3921
Abstract: Importance Tau accumulation in Alzheimer disease (AD) is closely associated with cognitive impairment. Quantitating tau accumulation by positron emission tomography (PET) will be a useful outcome measure for future clinical trials in the AD spectrum.… read more here.
Keywords: accumulation; pet; tau accumulation; suvr units ... See more keywords
Quantifying regional α ‐synuclein, amyloid β, and tau accumulation in lewy body dementia
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51482
Abstract: Parkinson disease (PD) is defined by the accumulation of misfolded α‐synuclein (α‐syn) in Lewy bodies and Lewy neurites. It affects multiple cortical and subcortical neuronal populations. The majority of people with PD develop dementia, which… read more here.
Keywords: body dementia; tau accumulation; accumulation; amyloid tau ... See more keywords
Tau Accumulation via Reduced Autophagy Mediates GGGGCC Repeat Expansion-Induced Neurodegeneration in Drosophila Model of ALS
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Bulletin"
DOI: 10.1007/s12264-020-00518-2
Abstract: Expansions of trinucleotide or hexanucleotide repeats lead to several neurodegenerative disorders, including Huntington disease [caused by expanded CAG repeats (CAGr) in the HTT gene], and amyotrophic lateral sclerosis [ALS, possibly caused by expanded GGGGCC repeats… read more here.
Keywords: neurodegeneration; tau accumulation; drosophila; autophagy ... See more keywords
Associations between baseline amyloid, sex, and APOE on subsequent tau accumulation in cerebrospinal fluid
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2019.02.019
Abstract: We investigated the effect of baseline Aβ, sex, and APOE on longitudinal tau accumulation in cerebrospinal fluid (CSF) in clinically normal older adults. Two hundred thirty-nine participants (aged 56-89 years, clinical dementia rating = 0) underwent serial CSF… read more here.
Keywords: tau; tau accumulation; csf; sex apoe ... See more keywords
Tau accumulation observed using repeated PET measures is associated with cognitive decline in normal elderly
Sign Up to like & getrecommendations! Published in 2018 at "Revue Neurologique"
DOI: 10.1016/j.neurol.2018.02.046
Abstract: Background Autopsy and early PET data suggest that cognition is more closely associated with tau than with amyloid pathology, including in clinically normal (CN) older adults. Recently acquired serial tau-PET data allowed us to assess… read more here.
Keywords: pet; tau; tau accumulation; cognitive decline ... See more keywords
Benzothiazole Substitution Analogs of Rhodacyanine Hsp70 Inhibitors Modulate Tau Accumulation.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00919
Abstract: The accumulation and aggregation of the microtubule-associated protein tau (tau) into intracellular neuronal tangles are a hallmark of a range of progressive neurodegenerative tauopathies, including Alzheimer's disease (AD), frontotemporal dementia, Pick's disease, and progressive supranuclear… read more here.
Keywords: tau; tau accumulation; accumulation; analogs rhodacyanine ... See more keywords
Prediction of tau accumulation in prodromal Alzheimer’s disease using an ensemble machine learning approach
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-85165-x
Abstract: We developed machine learning (ML) algorithms to predict abnormal tau accumulation among patients with prodromal AD. We recruited 64 patients with prodromal AD using the Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset. Supervised ML approaches based… read more here.
Keywords: machine; alzheimer disease; machine learning; tau accumulation ... See more keywords
Predicting future rates of tau accumulation on PET
Sign Up to like & getrecommendations! Published in 2020 at "Brain"
DOI: 10.1093/brain/awaa248
Abstract: Jack et al. show that in cognitively unimpaired individuals, the only independent predictor of high tau PET accumulation rates is amyloidosis. In cognitively impaired individuals, variables that are consistent with an early-onset Alzheimer’s disease phenotype… read more here.
Keywords: future rates; accumulation; tau accumulation; rates tau ... See more keywords
Phospho-tau with subthreshold tau-PET predicts increased tau accumulation rates in amyloid-positive individuals
Sign Up to like & getrecommendations! Published in 2022 at "Brain"
DOI: 10.1093/brain/awac329
Abstract: Abstract Different tau biomarkers become abnormal at different stages of Alzheimer’s disease, with CSF phospho-tau typically becoming elevated at subthreshold levels of tau-PET binding. To capitalize on the temporal order of tau biomarker-abnormality and capture… read more here.
Keywords: tau; tau pet; positive individuals; tau accumulation ... See more keywords
Plectin dysfunction in neurons leads to tau accumulation on microtubules affecting neuritogenesis, organelle trafficking, pain sensitivity and memory
Sign Up to like & getrecommendations! Published in 2020 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12635
Abstract: Plectin, a universally expressed multi‐functional cytolinker protein, is crucial for intermediate filament networking, including crosstalk with actomyosin and microtubules. In addition to its involvement in a number of diseases affecting skin, skeletal muscle, heart, and… read more here.
Keywords: plectin dysfunction; tau accumulation; leads tau; plectin ... See more keywords
The Mechanism of TNF-α-Mediated Accumulation of Phosphorylated Tau Protein and Its Modulation by Propofol in Primary Mouse Hippocampal Neurons: Role of Mitophagy, NLRP3, and p62/Keap1/Nrf2 Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/8661200
Abstract: Background Neuroinflammation-induced phosphorylated Tau (p-Tau) deposition in central nervous system contributes to neurodegenerative disorders. Propofol possesses neuroprotective properties. We investigated its impacts on tumor necrosis factor-α (TNF-α)-mediated p-Tau deposition in neurons. Methods Mouse hippocampal neurons… read more here.
Keywords: tnf; tau accumulation; keap1; accumulation ... See more keywords