Nitrosylation of GAPDH augments pathological tau acetylation upon exposure to amyloid-β
Sign Up to like & getrecommendations! Published in 2018 at "Science Signaling"
DOI: 10.1126/scisignal.aao6765
Abstract: Blocking the nitrosylation of GAPDH may reduce amyloid-induced tau toxicity in the brain and slow the progression of Alzheimer’s disease. Nitrosylation links amyloid and tau pathology Amyloid-β (Aβ), tau aggregates, and nitrosative stress all contribute… read more here.
Keywords: nitrosylation; tau acetylation; gapdh; pathology ... See more keywords
Decoding tau acetylation in Alzheimer’s disease and tauopathies: from site-specific mechanisms to therapeutic horizons
Sign Up to like & getrecommendations! Published in 2025 at "BMB Reports"
DOI: 10.5483/bmbrep.2025-0077
Abstract: Tau acetylation has been recognized as a pivotal post-translational modification associated with the pathogenesis of Alzheimer’s disease (AD) and other tauopathies. This review offers a detailed synthesis of the current understanding of site-specific tau acetylation,… read more here.
Keywords: alzheimer disease; disease tauopathies; tau acetylation; acetylation ... See more keywords