In Vivo Imaging of Tau Aggregates in the Mouse Retina.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6598-4_24
Abstract: Aggregates of hyperphosphorylated tau can be observed in the human brain affected by various neurodegenerative disorders. The development of a noninvasive technique for the visualization of these protein accumulations is a promising task. In the… read more here.
Keywords: tau; imaging tau; vivo; aggregates mouse ... See more keywords
Autophagic Pathways to Clear the Tau Aggregates in Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-020-00897-0
Abstract: Tau is a microtubule-associated protein with an intrinsically unstructured conformation. Tau is subjected to several pathological post-translational modifications (PTMs), leading to its loss of interaction with microtubules and accumulation as neurofibrillary tangles (NFTs) in neurons.… read more here.
Keywords: degradation; tau; pathways clear; tau aggregates ... See more keywords
AD molecular: Imaging tau aggregates with positron emissions tomography.
Sign Up to like & getrecommendations! Published in 2019 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2019.07.007
Abstract: Pathologic aggregates of tau protein are observed in several neurodegenerative diseases and are used to diagnose and stage disease postmortem. Recent advances in positron emission tomography radioligands allow for the detection of aggregated tau proteins… read more here.
Keywords: imaging tau; aggregates positron; tau aggregates; molecular imaging ... See more keywords
Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components
Sign Up to like & getrecommendations! Published in 2021 at "Neuron"
DOI: 10.1016/j.neuron.2021.03.026
Abstract: Tau aggregates contribute to neurodegenerative diseases, including frontotemporal dementia and Alzheimer's disease (AD). Although RNA promotes tau aggregation in vitro, whether tau aggregates in cells contain RNA is unknown. We demonstrate, in cell culture and mouse… read more here.
Keywords: tau; nuclear speckle; tau aggregates; aggregates rna ... See more keywords
Site-Specific Phospho-Tau Aggregation-Based Biomarker Discovery for AD Diagnosis and Differentiation.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00342
Abstract: Tau aggregates are present in multiple neurodegenerative diseases known as "tauopathies," including Alzheimer's disease (AD), Pick's disease (PiD), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD). Such misfolded tau aggregates are therefore potential sources for… read more here.
Keywords: site specific; tau aggregates; biomarker discovery; tau ... See more keywords
Development of a BODIPY-based fluorescent probe for imaging pathological tau aggregates in live cells.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c6cc08826k
Abstract: Neuronal accumulation of tau aggregates is a pathological hallmark in multiple neurodegenerative disorders, collectively called tauopathies. A tau aggregation sensor that can monitor abnormal tau aggregation in neurons would facilitate the study of tau aggregation… read more here.
Keywords: tau aggregation; tau; live cells; tau aggregates ... See more keywords
Tau aggregates: Where, When, Why and What consequences?
Sign Up to like & getrecommendations! Published in 2017 at "Neuropathology and applied neurobiology"
DOI: 10.1111/nan.12401
Abstract: Neuropathologists have been aware of neurofibrillary tangles for more than a century following their description as part of Alois Alzheimer's initial report. Since those early days, our understanding of the relationship of this particular type… read more here.
Keywords: tau aggregates; neurobiology; disease; aggregates consequences ... See more keywords
Propagation of Tau aggregates
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Brain"
DOI: 10.1186/s13041-017-0298-7
Abstract: Since 2009, evidence has accumulated to suggest that Tau aggregates form first in a small number of brain cells, from where they propagate to other regions, resulting in neurodegeneration and disease. Propagation of Tau aggregates… read more here.
Keywords: seed; tau; tau aggregates; brain ... See more keywords
[18F]-AV-1451 binding profile in chronic traumatic encephalopathy: a postmortem case series
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-019-0808-1
Abstract: IntroductionChronic traumatic encephalopathy (CTE) is a tauopathy associated to repetitive head trauma. There are no validated in vivo biomarkers of CTE and a definite diagnosis can only be made at autopsy. Recent studies have shown… read more here.
Keywords: tau; traumatic encephalopathy; 1451 binding; tau aggregates ... See more keywords