Crystal structure of the human tau PHF core domain VQIINK complexed with the Fab domain of monoclonal antibody Tau2r3
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13791
Abstract: Neurofibrillary tangles formed by abnormally aggregated tau protein are a histopathological feature of tauopathies. A tau aggregation inhibitor is a potential therapeutic agent for tauopathies. In this study, we prepared a monoclonal antibody for tau,… read more here.
Keywords: tau aggregation; crystal structure; domain; monoclonal antibody ... See more keywords
Thiophene‐Based Dual Modulators of Aβ and Tau Aggregation
Sign Up to like & getrecommendations! Published in 2021 at "ChemBioChem"
DOI: 10.1002/cbic.202100383
Abstract: Alzheimer's disease is characterized by the accumulation of amyloid beta (Aβ) and Tau aggregates in the brain, which induces various pathological events resulting in neurodegeneration. There have been continuous efforts to develop modulators of the… read more here.
Keywords: tau aggregation; based dual; thiophene based; modulators tau ... See more keywords
14-3-3/Tau Interaction and Tau Amyloidogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-019-01325-9
Abstract: The major function of microtubule-associated protein tau is to promote microtubule assembly in the central nervous system. However, aggregation of abnormally phosphorylated tau is a hallmark of tauopathies. Although the molecular mechanisms of conformational transitions… read more here.
Keywords: tau aggregation; interaction tau; tau; tau interaction ... See more keywords
Transition metal nickel prevents Tau aggregation in Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.11.176
Abstract: Alzheimer's disease is the leading cause of dementia, effecting majority of aged people worldwide. The multifaceted effectors of Alzheimer's disease primarily include Tau, amyloid-β along with hyper activation of kinases, oxidative stress and mutations etc.,… read more here.
Keywords: alzheimer disease; aggregation; nickel prevents; tau aggregation ... See more keywords
Effect of Melatonin on Tau aggregation and Tau-mediated cell surface morphology.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.01.296
Abstract: Aggregation of Microtubule-associated protein Tau and its deposition in the form of neurofibrillary tangles (NFTs) is one of the pathological hallmarks of Alzheimer's disease (AD). Tau aggregation inhibition has been targeted in various studies including… read more here.
Keywords: tau aggregation; aggregation; tau; effect ... See more keywords
Cobalt-based metal complexes prevent Repeat Tau aggregation and nontoxic to neuronal cells.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.02.278
Abstract: Alzheimer's disease (AD) is a fatal neurodegenerative disorder with an alarming increase in the death rate every year. AD is characterised by an aberrant accumulation of proteins in the form of aggregates. The axonal microtubule-associated… read more here.
Keywords: tau aggregation; aggregation; cobalt based; complexes prevent ... See more keywords
To target Tau pathologies, we must embrace and reconstruct their complexities
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2021.105536
Abstract: The accumulation of hyperphosphorylated fibrillar Tau aggregates in the brain is one of the defining hallmarks of Alzheimer's disease (AD) and other Tauopathies. However, the primary events or molecules responsible for triggering Tau aggregation and… read more here.
Keywords: tau aggregation; tau; aggregation pathology; pathology ... See more keywords
DJ-1 Molecular Chaperone Activity Depresses Tau Aggregation Propensity through Interaction with Monomers.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00581
Abstract: Tau aggregate-bearing lesions are pathological markers and potential mediators of tauopathic neurodegenerative diseases, including Alzheimer's disease. The molecular chaperone DJ-1 colocalizes with tau pathology in these disorders, but it has been unclear what functional link… read more here.
Keywords: chaperone; tau aggregation; chaperone activity; activity ... See more keywords
New Strategy for Reducing Tau Aggregation Cytologically by A Hairpinlike Molecular Inhibitor, Tannic Acid Encapsulated in Liposome.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00508
Abstract: Inhibition of Tau protein aggregation is an attractive therapeutic target for Alzheimer's disease. However, most of the inhibitors have failed in clinical trials due to the superficial understanding of inhibition mechanism and drug-transfer pharmacokinetics. Innovation… read more here.
Keywords: tau aggregation; tannic acid; molecular inhibitor; acid ... See more keywords
Dynamic interactions and Ca2+-binding modulate the holdase-type chaperone activity of S100B preventing tau aggregation and seeding
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-26584-2
Abstract: The microtubule-associated protein tau is implicated in the formation of oligomers and fibrillar aggregates that evade proteostasis control and spread from cell-to-cell. Tau pathology is accompanied by sustained neuroinflammation and, while the release of alarmin… read more here.
Keywords: tau aggregation; aggregation; tau; ca2 binding ... See more keywords
Development of a BODIPY-based fluorescent probe for imaging pathological tau aggregates in live cells.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c6cc08826k
Abstract: Neuronal accumulation of tau aggregates is a pathological hallmark in multiple neurodegenerative disorders, collectively called tauopathies. A tau aggregation sensor that can monitor abnormal tau aggregation in neurons would facilitate the study of tau aggregation… read more here.
Keywords: tau aggregation; tau; live cells; tau aggregates ... See more keywords