Tau in Alzheimer’s Disease: Pathological Alterations and an Attractive Therapeutic Target
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DOI: 10.1007/s11596-020-2282-1
Abstract: Alzheimer’s disease (AD) is an age-related neurodegenerative disease with two major hallmarks: extracellular amyloid plaques made of amyloid-β (Aβ) and intracellular neurofibrillary tangles (NFTs) of abnormally hyperphosphorylated tau. The number of NFTs correlates positively with… read more here.
Keywords: pathological alterations; disease pathological; tau alzheimer; alzheimer disease ... See more keywords
Synergy between amyloid-β and tau in Alzheimer’s disease
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DOI: 10.1038/s41593-020-0687-6
Abstract: Patients with Alzheimer’s disease (AD) present with both extracellular amyloid-β (Aβ) plaques and intracellular tau-containing neurofibrillary tangles in the brain. For many years, the prevailing view of AD pathogenesis has been that changes in Aβ… read more here.
Keywords: amyloid tau; tau alzheimer; alzheimer disease; disease ... See more keywords