Temporal trajectories of in vivo tau and amyloid-β accumulation in Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-020-04773-3
Abstract: Purpose To investigate the temporal trajectories of tau and amyloid-β (Aβ) accumulation in Alzheimer’s disease (AD) by using the longitudinal positron emission tomography (PET) study. Methods A total of 132 participants, who were healthy volunteers… read more here.
Keywords: accumulation; accumulation alzheimer; alzheimer disease; tau amyloid ... See more keywords
Transcriptional Signatures of Tau and Amyloid Neuropathology
Sign Up to like & getrecommendations! Published in 2020 at "Cell Reports"
DOI: 10.1016/j.celrep.2020.01.063
Abstract: Summary Alzheimer’s disease (AD) is associated with the intracellular aggregation of hyperphosphorylated tau and the accumulation of β-amyloid in the neocortex. We use transgenic mice harboring human tau (rTg4510) and amyloid precursor protein (J20) mutations… read more here.
Keywords: transcriptional signatures; signatures tau; neuropathology; pathology ... See more keywords
Tau and amyloid-related pathologies in the entorhinal cortex have divergent effects in the hippocampal circuit
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2017.08.015
Abstract: The entorhinal cortex (EC) is affected early in Alzheimer's disease, an illness defined by a co-occurrence of tau and amyloid-related pathologies. How the co-occurrence of these pathologies in the EC affects the hippocampal circuit remains… read more here.
Keywords: entorhinal cortex; amyloid related; hippocampal circuit; tau amyloid ... See more keywords
Specific Peptide from the Novel W-Tau Isoform Inhibits Tau and Amyloid β Peptide Aggregation In Vitro
Sign Up to like & getrecommendations! Published in 2022 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.2c00188
Abstract: W-Tau, a new tau human-specific splicing isoform generated by intron retention, has been recently described. This isoform contains an 18-residue unique sequence corresponding to the translation of the retained region of intron 12. In this… read more here.
Keywords: isoform; tau amyloid; peptide; specific peptide ... See more keywords
A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Nature Medicine"
DOI: 10.1038/s41591-020-0781-z
Abstract: Development of tau-based therapies for Alzheimer’s disease requires an understanding of the timing of disease-related changes in tau. We quantified the phosphorylation state at multiple sites of the tau protein in cerebrospinal fluid markers across… read more here.
Keywords: alzheimer disease; inherited alzheimer; disease; pathology ... See more keywords
Natural inhibitors for acetylcholinesterase and autophagy modulators as effective antagonists for tau and β-amyloid in Alzheimer’s rat model
Sign Up to like & getrecommendations! Published in 2023 at "Biomarkers"
DOI: 10.1080/1354750x.2022.2164617
Abstract: Abstract Background: Phytochemicals have amazing biological effects in relation to age-related illnesses and are increasingly being studied in clinical trials. The goal of this study was to examine the effectiveness of the aqueous extracts of… read more here.
Keywords: rat model; alzheimer rat; tau amyloid; natural inhibitors ... See more keywords
Altered excitatory and inhibitory neuronal subpopulation parameters are distinctly associated with tau and amyloid in Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.03.09.483594
Abstract: Background Neuronal and circuit level abnormalities of excitation and inhibition are shown to be associated with tau and amyloid-beta (Aβ) in preclinical models of Alzheimer’s disease (AD). These relationships remain poorly understood in patients with… read more here.
Keywords: tau; associated tau; alzheimer disease; tau amyloid ... See more keywords
Plasma extracellular vesicle tau, β-amyloid, and α-synuclein and the progression of Parkinson’s disease: a follow-up study
Sign Up to like & getrecommendations! Published in 2023 at "Therapeutic Advances in Neurological Disorders"
DOI: 10.1177/17562864221150329
Abstract: Background: Plasma extracellular vesicle (EV) contents are promising biomarkers of Parkinson’s disease (PD). The pathognomonic proteins of PD, including α-synuclein, tau, and β-amyloid, are altered in people with PD (PwP) and are associated with clinical… read more here.
Keywords: tau; progression; synuclein; tau amyloid ... See more keywords
Association of APOE4 and Clinical Variability in Alzheimer Disease With the Pattern of Tau- and Amyloid-PET
Sign Up to like & getrecommendations! Published in 2021 at "Neurology"
DOI: 10.1212/wnl.0000000000011270
Abstract: Objective To assess whether Alzheimer disease (AD) clinical presentation and APOE4 relate to the burden and topography of β-amyloid (Aβ) and tau pathologies using in vivo PET imaging. Methods We studied 119 Aβ-positive symptomatic patients… read more here.
Keywords: pathology; tau amyloid; alzheimer disease; pet ... See more keywords
Comparison of Tau and Amyloid-β Targeted Immunotherapy Nanoparticles for Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12071001
Abstract: Alzheimer’s disease (AD) is a rapidly growing global concern associated with the accumulation of amyloid-β plaques and intracellular neurofibrillary tangles in the brain combined with a high acetylcholinesterase activity. AD diagnosis is usually made too… read more here.
Keywords: alzheimer disease; brain; tau amyloid; amyloid ... See more keywords