N-terminal and mid-region tau fragments as fluid biomarkers in neurological diseases
Sign Up to like & getrecommendations! Published in 2022 at "Brain"
DOI: 10.1093/brain/awab481
Abstract: Abstract Brain-derived tau secreted into CSF and blood consists of different N-terminal and mid-domain fragments, which may have a differential temporal course and thus, biomarker potential across the Alzheimer’s disease continuum or in other neurological… read more here.
Keywords: tau; alzheimer disease; tau biomarkers; neurological diseases ... See more keywords
Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer’s continuum when only subtle changes in Aβ pathology are detected
Sign Up to like & getrecommendations! Published in 2020 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.202012921
Abstract: In Alzheimer’s disease (AD), tau phosphorylation in the brain and its subsequent release into cerebrospinal fluid (CSF) and blood is a dynamic process that changes during disease evolution. The main aim of our study was… read more here.
Keywords: alzheimer continuum; preclinical alzheimer; tau; novel tau ... See more keywords