Association of Klotho Protein Levels and KL-VS Heterozygosity With Alzheimer Disease and Amyloid and Tau Burden
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.43232
Abstract: Key Points Question What is the association between Klotho protein levels in cerebrospinal fluid (CSF) and plasma, heterozygosity status of the KL-VS haplotype, and amyloid and tau burden among cognitively healthy controls and patients with… read more here.
Keywords: amyloid tau; heterozygosity; protein levels; klotho protein ... See more keywords
Association of Aortic Stiffness and Pressure Pulsatility With Global Amyloid-β and Regional Tau Burden Among Framingham Heart Study Participants Without Dementia.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2022.1261
Abstract: Importance Aortic stiffness is associated with clinical hallmarks of Alzheimer disease and related dementias and could be a modifiable target for disease prevention. Objective To assess associations of aortic stiffness and pressure pulsatility with global… read more here.
Keywords: pressure; aortic stiffness; tau burden;
Affective symptoms and regional cerebral tau burden in early‐stage Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Geriatric Psychiatry"
DOI: 10.1002/gps.5530
Abstract: Neuropsychiatric symptoms (NPS) are often present in individuals with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia. NPS are associated with structural and functional changes in the brain such as atrophy, regional hypometabolism, and… read more here.
Keywords: alzheimer disease; cerebral tau; regional cerebral; tau burden ... See more keywords
Tau burden and the functional connectome in Alzheimer’s disease and progressive supranuclear palsy
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DOI: 10.1093/brain/awx347
Abstract: Prion-like, trans-neuronal spread of tau pathology in humans is controversial. By evaluating tau burden and functional connectivity in living patients, Cope et al. demonstrate relationships consistent with this in Alzheimer's disease but not progressive supranuclear… read more here.
Keywords: tau; alzheimer disease; burden functional; tau burden ... See more keywords
Distinct subcortical tau burden: The tau pallido-claustral ratio separates progressive supranuclear palsy and corticobasal degeneration.
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DOI: 10.1111/bpa.13030
Abstract: Neuropathological diagnosis of progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) requires interpretation of tau morphology based on extensive brain sampling. Here we report subcortical tau burden is sufficient to distinguish PSP and CBD, regardless… read more here.
Keywords: tau; supranuclear palsy; subcortical tau; corticobasal degeneration ... See more keywords