Assessment of the In Vivo Relationship Between Cerebral Hypometabolism, Tau Deposition, TSPO Expression, and Synaptic Density in a Tauopathy Mouse Model: a Multi-tracer PET Study.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular neurobiology"
DOI: 10.1007/s12035-022-02793-8
Abstract: Cerebral glucose hypometabolism is a typical hallmark of Alzheimer's disease (AD), usually associated with ongoing neurodegeneration and neuronal dysfunction. However, underlying pathological processes are not fully understood and reproducibility in animal models is not well… read more here.
Keywords: study; tspo expression; tau deposition; hypometabolism ... See more keywords
Aerobic glycolysis and tau deposition in preclinical Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2018.03.014
Abstract: Research of the human brain metabolism in vivo has largely focused on total glucose use (via fluorodeoxyglucose positron emission tomography) and, until recently, did not examine the use of glucose outside oxidative phosphorylation, which is known… read more here.
Keywords: deposition; alzheimer disease; aerobic glycolysis; tau deposition ... See more keywords
Association of enlarged perivascular spaces with Aβ and tau deposition in cognitively normal older population
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2020.12.014
Abstract: The relationship between magnetic resonance imaging (MRI)-visible enlarged perivascular spaces (EPVS) and Aβ and tau deposition is poorly investigated in cognitively normal older population. In our study, a total of 106 cognitively normal older subjects… read more here.
Keywords: high degree; cognitively normal; epvs; degree ... See more keywords
Regional differences in glucose metabolic decline and tau deposition in the Alzheimer's continuum brain
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Alzheimer's Disease"
DOI: 10.1177/13872877241284314
Abstract: Background: Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β and tau proteins, leading to neurofibrillary tangles. A biomarker-based diagnostic method called the ATN system categorizes AD pathology into amyloid-β (A), tau (T), and… read more here.
Keywords: pet; tau deposition; tau; glucose metabolism ... See more keywords
Association of hippocampal atrophy with tau pathology of temporal regions in preclinical Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Alzheimer's Disease"
DOI: 10.1177/13872877251314785
Abstract: Background Hippocampal atrophy is linked to memory and cognitive deficits, preceding clinical diagnosis of mild cognitive impairment (MCI) by decades. Morphometry changes in the hippocampal formation (HF) and their relationship to tau deposition in non-demented… read more here.
Keywords: temporal regions; pathology; tau deposition; hippocampal atrophy ... See more keywords
Astrocyte tau deposition in progressive supranuclear palsy is associated with dysregulation of MAPT transcription
Sign Up to like & getrecommendations! Published in 2024 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-024-01844-6
Abstract: Progressive supranuclear palsy (PSP) is a neurodegenerative disease characterized by 4R tau deposition in neurons as well as in astrocytes and oligodendrocytes. While astrocytic tau deposits are rarely observed in normal aging (so-called aging-related tau… read more here.
Keywords: astrocytic tau; progressive supranuclear; supranuclear palsy; tau ... See more keywords
White Matter Degeneration Pathways Associated With Tau Deposition in Alzheimer Disease
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000207250
Abstract: Background and Objectives The dynamics of white matter (WM) changes are understudied in Alzheimer disease (AD). Our goal was to study the association between flortaucipir PET and WM health using neurite orientation dispersion and density… read more here.
Keywords: braak; degeneration; white matter; disease ... See more keywords
Functional Abnormality Associated With Tau Deposition in Alzheimer’s Disease – A Hybrid Positron Emission Tomography/MRI Study
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2021.758053
Abstract: Objective: To investigate the characteristics of tau deposition and its impact on functional connectivity (FC) in Alzheimer’s disease (AD). Methods: Hybrid PET/MRI scans with [18F]-THK5317 and neuropsychological assessments were undertaken in 26 participants with AD… read more here.
Keywords: 18f thk5317; alzheimer disease; deposition; functional abnormality ... See more keywords