Assessment of the In Vivo Relationship Between Cerebral Hypometabolism, Tau Deposition, TSPO Expression, and Synaptic Density in a Tauopathy Mouse Model: a Multi-tracer PET Study.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular neurobiology"
DOI: 10.1007/s12035-022-02793-8
Abstract: Cerebral glucose hypometabolism is a typical hallmark of Alzheimer's disease (AD), usually associated with ongoing neurodegeneration and neuronal dysfunction. However, underlying pathological processes are not fully understood and reproducibility in animal models is not well… read more here.
Keywords: study; tspo expression; tau deposition; hypometabolism ... See more keywords
Aerobic glycolysis and tau deposition in preclinical Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2018.03.014
Abstract: Research of the human brain metabolism in vivo has largely focused on total glucose use (via fluorodeoxyglucose positron emission tomography) and, until recently, did not examine the use of glucose outside oxidative phosphorylation, which is known… read more here.
Keywords: deposition; alzheimer disease; aerobic glycolysis; tau deposition ... See more keywords
Association of enlarged perivascular spaces with Aβ and tau deposition in cognitively normal older population
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2020.12.014
Abstract: The relationship between magnetic resonance imaging (MRI)-visible enlarged perivascular spaces (EPVS) and Aβ and tau deposition is poorly investigated in cognitively normal older population. In our study, a total of 106 cognitively normal older subjects… read more here.
Keywords: high degree; cognitively normal; epvs; degree ... See more keywords
White Matter Degeneration Pathways Associated With Tau Deposition in Alzheimer Disease
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DOI: 10.1212/wnl.0000000000207250
Abstract: Background and Objectives The dynamics of white matter (WM) changes are understudied in Alzheimer disease (AD). Our goal was to study the association between flortaucipir PET and WM health using neurite orientation dispersion and density… read more here.
Keywords: braak; degeneration; white matter; disease ... See more keywords
Functional Abnormality Associated With Tau Deposition in Alzheimer’s Disease – A Hybrid Positron Emission Tomography/MRI Study
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2021.758053
Abstract: Objective: To investigate the characteristics of tau deposition and its impact on functional connectivity (FC) in Alzheimer’s disease (AD). Methods: Hybrid PET/MRI scans with [18F]-THK5317 and neuropsychological assessments were undertaken in 26 participants with AD… read more here.
Keywords: 18f thk5317; alzheimer disease; deposition; functional abnormality ... See more keywords