Cryptic Sites in Tau Fibrils Explain the Preferential Binding of the AV-1451 PET Tracer toward Alzheimer’s Tauopathy
Sign Up to like & getrecommendations! Published in 2021 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.0c00340
Abstract: Tauopathies are a subclass of neurodegenerative diseases characterized by an accumulation of microtubule binding tau fibrils in brain regions. Diseases such as Alzheimer’s (AD), chronic traumatic encephalopathy (CTE), Pick’s disease (PiD), and corticobasal degeneration (CBD)… read more here.
Keywords: affinity; tracer toward; tracer; cryptic sites ... See more keywords
D-peptide-magnetic nanoparticles fragment tau fibrils and rescue behavioral deficits in a mouse model of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2024 at "Science Advances"
DOI: 10.1126/sciadv.adl2991
Abstract: Amyloid fibrils of tau are increasingly accepted as a cause of neuronal death and brain atrophy in Alzheimer’s disease (AD). Diminishing tau aggregation is a promising strategy in the search for efficacious AD therapeutics. Previously,… read more here.
Keywords: alzheimer disease; tau aggregation; mouse model; tau fibrils ... See more keywords
Tau fibrils evade autophagy by excessive p62 coating and TAX1BP1 exclusion
Sign Up to like & getrecommendations! Published in 2024 at "Science Advances"
DOI: 10.1126/sciadv.adm8449
Abstract: The accumulation of protein aggregates is a hallmark of many diseases, including Alzheimer’s disease. As a major pillar of the proteostasis network, autophagy mediates the degradation of protein aggregates. The autophagy cargo receptor p62 recognizes… read more here.
Keywords: fibrils evade; tau fibrils; tau; protein aggregates ... See more keywords
Astrocytic accumulation of tau fibrils isolated from Alzheimer’s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment
Sign Up to like & getrecommendations! Published in 2024 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-024-01745-8
Abstract: Accumulating evidence highlights the involvement of astrocytes in Alzheimer’s disease (AD) progression. We have previously demonstrated that human iPSC-derived astrocytes ingest and modify synthetic tau fibrils in a way that enhances their seeding efficiency. However,… read more here.
Keywords: alzheimer disease; tau fibrils; tau; cell ... See more keywords
Recent Advances in Molecular Dynamics Simulations of Tau Fibrils and Oligomers
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DOI: 10.3390/membranes13030277
Abstract: The study of tau protein aggregation and interactions with other molecules or solvents using molecular dynamics simulations (MDs) is of interest to many researchers to propose new mechanism-based therapeutics for neurodegenerative diseases such as Alzheimer’s… read more here.
Keywords: dynamics simulations; tau; tau fibrils; molecular dynamics ... See more keywords