Ordered Assembly of Tau Protein and Neurodegeneration.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-32-9358-8_1
Abstract: Tau filaments with distinct morphologies and/or isoform compositions underlie a large number of human neurodegenerative diseases. Their formation is important, because dominantly inherited mutations in MAPT, the tau gene, cause frontotemporal dementia with abundant filamentous… read more here.
Keywords: tau; amino acids; tau filaments; disease ... See more keywords
Cryo-EM structures of tau filaments from Alzheimer’s disease with PET ligand APN-1607
Sign Up to like & getrecommendations! Published in 2021 at "Acta Neuropathologica"
DOI: 10.1007/s00401-021-02294-3
Abstract: Tau and Aβ assemblies of Alzheimer’s disease (AD) can be visualized in living subjects using positron emission tomography (PET). Tau assemblies comprise paired helical and straight filaments (PHFs and SFs). APN-1607 (PM-PBB3) is a recently… read more here.
Keywords: tau; alzheimer disease; tau filaments; apn 1607 ... See more keywords
Structure of Tau filaments in Prion protein amyloidoses
Sign Up to like & getrecommendations! Published in 2021 at "Acta Neuropathologica"
DOI: 10.1007/s00401-021-02336-w
Abstract: In human neurodegenerative diseases associated with the intracellular aggregation of Tau protein, the ordered cores of Tau filaments adopt distinct folds. Here, we analyze Tau filaments isolated from the brain of individuals affected by Prion-Protein… read more here.
Keywords: protein; tau; q160x; prp caa ... See more keywords
Distinct Conformers of Assembled Tau in Alzheimer's and Pick's Diseases.
Sign Up to like & getrecommendations! Published in 2019 at "Cold Spring Harbor symposia on quantitative biology"
DOI: 10.1101/sqb.2018.83.037580
Abstract: Tau filaments with distinct morphologies and/or isoform compositions underlie a large number of human neurodegenerative diseases. In conjunction with experimental studies, this has led to the suggestion that conformers of aggregated tau exist. Electron cryo-microscopy… read more here.
Keywords: tau; amino acids; distinct conformers; conformers assembled ... See more keywords
Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.43584
Abstract: Assembly of microtubule-associated protein tau into filamentous inclusions underlies a range of neurodegenerative diseases. Tau filaments adopt different conformations in Alzheimer’s and Pick’s diseases. Here, we used cryo- and immuno- electron microscopy to characterise filaments… read more here.
Keywords: induced tau; alzheimer pick; heparin induced; pick diseases ... See more keywords