Regulation of Tau Homeostasis and Toxicity by Acetylation.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-32-9358-8_4
Abstract: Multiple neurodegenerative conditions including Alzheimer's disease and frontotemporal dementia are characterized by the accumulation of tau in the brain, associated with synapse loss and cognitive decline. Currently, the molecular events that lead to tau aggregation,… read more here.
Keywords: tau homeostasis; acetylation; tau; toxicity acetylation ... See more keywords
A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology
Sign Up to like & getrecommendations! Published in 2018 at "Nature neuroscience"
DOI: 10.1038/s41593-018-0298-7
Abstract: Excitatory neurons are preferentially impaired in early Alzheimer’s disease but the pathways contributing to their relative vulnerability remain largely unknown. Here we report that pathological tau accumulation takes place predominantly in excitatory neurons compared to… read more here.
Keywords: homeostasis signature; excitatory neurons; tau homeostasis; pathology ... See more keywords