Ultrasmall Nanoparticles Mitigate Tau Hyperphosphorylation to Restore Synaptic Integrity and Boost Cognitive Function in Alzheimer's Disease
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202500941
Abstract: Tau hyperphosphorylation represents a critical pathological hallmark of Alzheimer's disease (AD), a prevalent neurodegenerative disorder characterized by progressive cognitive decline. The ubiquitin‐specific proteases 14 (USP14) impairs proteasomal function and accelerates hyperphosphorylated Tau accumulation, making it… read more here.
Keywords: alzheimer disease; synaptic integrity; tau hyperphosphorylation; hyperphosphorylation ... See more keywords
Natural products against tau hyperphosphorylation‐induced aggregates: Potential therapies for Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2025 at "Archiv Der Pharmazie"
DOI: 10.1002/ardp.202400721
Abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory impairments and is considered the most prevalent form of dementia. Among the contributing factors to AD lies the hyperphosphorylation of the… read more here.
Keywords: alzheimer disease; hyperphosphorylation induced; natural products; tau hyperphosphorylation ... See more keywords
APOE4 promotes nigral tau hyperphosphorylation through cholesterol in atherosclerosis
Sign Up to like & getrecommendations! Published in 2025 at "Cell Death Discovery"
DOI: 10.1038/s41420-025-02778-1
Abstract: Nigral tau hyperphosphorylation has been implicated as an initiation of nigrostriatal dopaminergic neurodegeneration. Apolipoprotein epsilon 4 allele (APOE4) is a common risk factor of Parkinson’s disease (PD) and atherosclerosis (AS). Whether APOE4 carriers exhibited higher… read more here.
Keywords: apoe4; pathology; tau; tau hyperphosphorylation ... See more keywords
Toxoplasma GRA16 attenuates Tau hyperphosphorylation and enhances autophagy in thrombin-treated HT-22 hippocampal neuronal cells
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-00271-4
Abstract: This study investigated whether Toxoplasma gondii-derived dense granule protein 16 (GRA16) modulates tau protein to attenuate tau hyperphosphorylation and promotes autophagy to facilitate the removal of tau aggregates. HT-22 murine hippocampal neuronal cells were treated… read more here.
Keywords: thrombin treated; pathology; hippocampal neuronal; tau hyperphosphorylation ... See more keywords
Treponema denticola Induces Alzheimer-Like Tau Hyperphosphorylation by Activating Hippocampal Neuroinflammation in Mice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of dental research"
DOI: 10.1177/00220345221076772
Abstract: Alzheimer's disease (AD) is the most common type of dementia. Tau hyperphosphorylation and amyloid β (Aβ) deposition are the key pathological hallmarks of AD. Recent studies have shown that periodontitis is a significant risk factor… read more here.
Keywords: tau; treponema denticola; tau hyperphosphorylation; mice ... See more keywords
Torpor induces reversible tau hyperphosphorylation and accumulation in mice expressing human tau
Sign Up to like & getrecommendations! Published in 2024 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-024-01800-4
Abstract: Tau protein hyperphosphorylation and aggregation are key pathological events in neurodegenerative tauopathies such as Alzheimer’s disease. Interestingly, seasonal hibernators show extensive tau hyperphosphorylation during torpor, i.e., the hypothermic and hypometabolic state of hibernation, which is… read more here.
Keywords: mice; human tau; tau hyperphosphorylation; tau ... See more keywords
Screening of tau protein kinase inhibitors in a tauopathy-relevant cell-based model of tau hyperphosphorylation and oligomerization
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0224952
Abstract: Tauopathies are a class of neurodegenerative disorders characterized by abnormal deposition of post-translationally modified tau protein in the human brain. Tauopathies are associated with Alzheimer’s disease (AD), chronic traumatic encephalopathy (CTE), and other diseases. Hyperphosphorylation… read more here.
Keywords: hyperphosphorylation oligomerization; inhibitor; kinase; hyperphosphorylation ... See more keywords
NAP Protects against Tau Hyperphosphorylation Through GSK3.
Sign Up to like & getrecommendations! Published in 2018 at "Current pharmaceutical design"
DOI: 10.2174/1381612824666181112105954
Abstract: BACKGROUND The most common form of dementia is Alzheimer's disease (AD), which is characterized, in part, by the accumulation of neurofibrillary tangles (NFT), followed by synaptic and neuronal loss. NFTs are mainly composed of aggregated… read more here.
Keywords: tau; zinc; activity; nap protects ... See more keywords
Amelioration of Hippocampal Insulin Resistance Reduces Tau Hyperphosphorylation and Cognitive Decline Induced by Isoflurane in Mice
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2021.686506
Abstract: General anesthetics can induce cognitive impairments and increase the risk of Alzheimer’s disease (AD). However, the underlying mechanisms are still unknown. Our previous studies shown that long-term isoflurane exposure induced peripheral and central insulin resistance… read more here.
Keywords: insulin; mice; isoflurane; cognitive decline ... See more keywords
Similarities and Differences in the Pattern of Tau Hyperphosphorylation in Physiological and Pathological Conditions: Impacts on the Elaboration of Therapies to Prevent Tau Pathology
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2020.607680
Abstract: Tau protein, a neuronal microtubule-associated protein, becomes hyperphosphorylated in several neurodegenerative diseases called tauopathies. Hyperphosphorylation of tau is correlated to its redistribution from the axon to the somato-dendritic compartment at early stages of tauopathies. Interestingly,… read more here.
Keywords: physiological pathological; pathological conditions; pathology; hyperphosphorylation ... See more keywords
HIF-1α Causes LCMT1/PP2A Deficiency and Mediates Tau Hyperphosphorylation and Cognitive Dysfunction during Chronic Hypoxia
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232416140
Abstract: Chronic hypoxia is a risk factor for Alzheimer’s disease (AD), and the neurofibrillary tangle (NFT) formed by hyperphosphorylated tau is one of the two major pathological changes in AD. However, the effect of chronic hypoxia… read more here.
Keywords: hif; hypoxia; chronic hypoxia; tau hyperphosphorylation ... See more keywords