Human Tau Isoforms and Proteolysis for Production of Toxic Tau Fragments in Neurodegeneration
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2021.702788
Abstract: The human tau protein is implicated in a wide range of neurodegenerative “tauopathy” diseases, consisting of Alzheimer’s disease (AD) and frontotemporal lobar degeneration which includes progressive supranuclear palsy, corticobasal degeneration, Pick’s disease, and FTLD-tau (frontotemporal… read more here.
Keywords: tau; toxic tau; human tau; tau fragments ... See more keywords
Differential Effects of Human Tau Isoforms to Neuronal Dysfunction and Toxicity in the Drosophila CNS
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DOI: 10.3390/ijms232112985
Abstract: Accumulation of highly post-translationally modified tau proteins is a hallmark of neurodegenerative disorders known as tauopathies, the most common of which is Alzheimer’s disease. Although six tau isoforms are found in the human brain, the… read more here.
Keywords: tau; tau isoforms; neuronal dysfunction; dysfunction toxicity ... See more keywords
Tau Isoforms: Gaining Insight into MAPT Alternative Splicing
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DOI: 10.3390/ijms232315383
Abstract: Tau microtubule-associated proteins, encoded by the MAPT gene, are mainly expressed in neurons participating in axonal transport and synaptic plasticity. Six major isoforms differentially expressed during cell development and differentiation are translated by alternative splicing… read more here.
Keywords: tau; tau isoforms; isoforms gaining; alternative splicing ... See more keywords