Physiological clearance of tau in the periphery and its therapeutic potential for tauopathies
Sign Up to like & getrecommendations! Published in 2018 at "Acta Neuropathologica"
DOI: 10.1007/s00401-018-1891-2
Abstract: Accumulation of pathological tau is the hallmark of Alzheimer’s disease and other tauopathies and is closely correlated with cognitive decline. Clearance of pathological tau from the brain is a major therapeutic strategy for tauopathies. The… read more here.
Keywords: tau levels; tau; pathological tau; clearance ... See more keywords
Alzheimer’s disease susceptibility locus in CD2AP is associated with increased cerebrospinal fluid tau levels in mild cognitive impairment
Sign Up to like & getrecommendations! Published in 2022 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2021.136419
Abstract: INTRODUCTION Rs9296559 within CD2-associated protein (CD2AP) has been identified as a susceptibility locus for Alzheimer's disease (AD). Recent studies indicated that CD2AP functioned as a regulator of endocytic trafficking to modulate the β-amyloid (Aβ) generation… read more here.
Keywords: cd2ap; tau; susceptibility locus; tau levels ... See more keywords
Elevated Tau and β-amyloid in the Serum of Fibromyalgia Patients.
Sign Up to like & getrecommendations! Published in 2020 at "CNS spectrums"
DOI: 10.1017/s1092852920002114
Abstract: Fibromyalgia (FM) is a chronic widespread pain syndrome. Although its mechanism remains relatively unknown, accelerated neurodegeneration in the brain has been reported in patients with FM. Sleep disturbance can increase the risk of neurocognitive disorders,… read more here.
Keywords: serum; tau levels; serum tau; sleep disturbance ... See more keywords
Cross-sectional associations of CSF tau levels with Rey's AVLT: A recency ratio study.
Sign Up to like & getrecommendations! Published in 2022 at "Neuropsychology"
DOI: 10.1037/neu0000821
Abstract: OBJECTIVE The preeminent in vivo cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) are amyloid β 1-42 (Aβ42), phosphorylated Tau (p-tau), and total Tau (t-tau). The goal of this study was to examine how well… read more here.
Keywords: tau; csf; recency ratio; csf tau ... See more keywords
Association of tear fluid amyloid and tau levels with disease severity and neurodegeneration
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-01993-x
Abstract: There has been increasing interest in finding non-invasive biomarkers for neurodegenerative diseases such as Alzheimer’s disease (AD). This observational study investigated AD-specific biomarkers in tear fluid. Tear fluid was collected from a total of 65… read more here.
Keywords: tau levels; tau; neurodegeneration; tear fluid ... See more keywords
Pathogenic cis p-tau levels in CSF reflects severity of traumatic brain injury.
Sign Up to like & getrecommendations! Published in 2022 at "Neurological research"
DOI: 10.1080/01616412.2021.2022921
Abstract: Traumatic brain injury (TBI) is the main cause of death and disability among young people. Following TBI, immune system activation and cytokine release induce kinase activity and hyperphosphorylation of tau protein, a structural molecule in… read more here.
Keywords: tau levels; tau; cis tau; csf cis ... See more keywords
Numb regulates Tau levels and prevents neurodegeneration in tauopathy mouse models
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abm4295
Abstract: Accumulation of the microtubule-associated protein Tau is linked to neuronal cell death in tauopathies, but how intraneuronal Tau levels are regulated in health and disease remains unclear. Here, we show that conditional inactivation of the… read more here.
Keywords: tau; levels prevents; mouse; numb regulates ... See more keywords
Plasma Tau Levels in Cognitively Normal Middle-Aged and Older Adults
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2017.00051
Abstract: Using an ultra-sensitive technique, an immunomagnetic reduction assay, the plasma tau level can be measured to a limit of quantification of pg/ml. In total 126 cognitively normal middle-aged and older adults (45–95 years old) were… read more here.
Keywords: tau levels; tau; plasma tau; cognitively normal ... See more keywords
Plasma Levels of Aβ42 and Tau Identified Probable Alzheimer’s Dementia: Findings in Two Cohorts
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2017.00226
Abstract: The utility of plasma amyloid beta (Aβ) and tau levels for the clinical diagnosis of Alzheimer’s disease (AD) dementia has been controversial. The main objective of this study was to compare Aβ42 and tau levels… read more here.
Keywords: tau levels; plasma; dementia; alzheimer ... See more keywords