Tracking Tau in Neurons: How to Grow, Fix, and Stain Primary Neurons for the Investigation of Tau in All Developmental Stages.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6598-4_20
Abstract: Primary neurons have proved to be an invaluable tool for the investigation of Tau in the context of neuronal development and neurodegeneration. Culturing neurons usually is time consuming and requires multiple feeding steps and media… read more here.
Keywords: tracking tau; tau neurons; primary neurons; investigation tau ... See more keywords
Tracking Tau in Neurons: How to Transfect and Track Exogenous Tau into Primary Neurons.
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DOI: 10.1007/978-1-4939-6598-4_21
Abstract: Primary neurons have proved to be an essential tool for investigating neuronal polarity in general and polarized Tau distribution in particular. However, mature primary neurons are notoriously difficult to transfect with nonviral vectors and are… read more here.
Keywords: tracking tau; tau; primary neurons; tau neurons ... See more keywords
Optical induction of autophagy via Transcription factor EB (TFEB) reduces pathological tau in neurons
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DOI: 10.1371/journal.pone.0230026
Abstract: Pathological accumulation of microtubule associated protein tau in neurons is a major neuropathological hallmark of Alzheimer’s disease (AD) and related tauopathies. Several attempts have been made to promote clearance of pathological tau (p-Tau) from neurons.… read more here.
Keywords: transcription factor; autophagy; tau neurons; tfeb ... See more keywords
Tau Positive Neurons Show Marked Mitochondrial Loss and Nuclear Degradation in Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2018 at "Current Alzheimer research"
DOI: 10.2174/1567205015666180613115644
Abstract: BACKGROUND Alzheimer's disease (AD) pathology consists of intraneuronal neurofibrillary tangles, made of hyperphosphorylated tau and extracellular accumulation of beta amyloid (Aβ) in Aβ plaques. There is an extensive debate as to which pathology initiates and… read more here.
Keywords: tau positive; tau; tau neurons; pathology ... See more keywords