Near Infrared Light Treatment Reduces Synaptic Levels of Toxic Tau Oligomers in Two Transgenic Mouse Models of Human Tauopathies
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1248-9
Abstract: Tau oligomers are emerging as a key contributor to the synaptic dysfunction that drives cognitive decline associated with the clinical manifestation and progression of Alzheimer’s disease (AD). Accordingly, there is ample consensus that interventions that… read more here.
Keywords: nir light; treatment; near infrared; tau oligomers ... See more keywords
Preparation of stable tau oligomers for cellular and biochemical studies
Sign Up to like & getrecommendations! Published in 2019 at "Analytical Biochemistry"
DOI: 10.1016/j.ab.2018.10.013
Abstract: Increasing evidence suggests that small oligomers are the principal neurotoxic species of tau in Alzheimer's disease and other tauopathies. However, mechanisms of tau oligomer-mediated neurodegeneration are poorly understood. The transience of oligomers due to aggregation… read more here.
Keywords: cellular biochemical; tau; oligomers cellular; preparation stable ... See more keywords
Passive immunotherapies targeting amyloid beta and tau oligomers in Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2019.10.024
Abstract: Alzheimer's disease (AD) is historically difficult to treat, in part due the inaccessible nature of brain pathology. Amyloid-β (Aβ) and tau proteins drive pathology by forming toxic oligomers that eventually deposit as insoluble amyloid plaques… read more here.
Keywords: alzheimer disease; passive immunotherapies; tau oligomers; pathology ... See more keywords
Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives
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DOI: 10.1038/s41598-019-55419-w
Abstract: The pathological aggregation and accumulation of tau, a microtubule-associated protein, is a common feature amongst more than 18 different neurodegenerative diseases that are collectively known as tauopathies. Recently, it has been demonstrated that the soluble… read more here.
Keywords: aggregation; tau; toxic tau; curcumin derivatives ... See more keywords
Binding and neurotoxicity mitigation of toxic tau oligomers by synthetic heparin like oligosaccharides.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc05072d
Abstract: Well-defined heparin like oligosaccharides up to decasaccharides were synthesized. It was discovered for the first time that heparin oligosaccharides, as short as tetrasaccharides, can bind with the most toxic tau species, i.e., tau oligomers with… read more here.
Keywords: heparin like; like oligosaccharides; tau oligomers; toxic tau ... See more keywords
Extracellular tau oligomers affect extracellular glutamate handling by astrocytes through downregulation of GLT‐1 expression and impairment of NKA1A2 function
Sign Up to like & getrecommendations! Published in 2022 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12811
Abstract: Several studies reported that astrocytes support neuronal communication by the release of gliotransmitters, including ATP and glutamate. Astrocytes also play a fundamental role in buffering extracellular glutamate in the synaptic cleft, thus limiting the risk… read more here.
Keywords: glutamate; tau oligomers; oligomers affect; extracellular tau ... See more keywords
Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer’s Disease and Related Tauopathies
Sign Up to like & getrecommendations! Published in 2017 at "Aging and Disease"
DOI: 10.14336/ad.2017.0112
Abstract: The importance of vascular contributions to cognitive impairment and dementia (VCID) associated with Alzheimer’s disease (AD) and related neurodegenerative diseases is increasingly recognized, however, the underlying mechanisms remain obscure. There is growing evidence that in… read more here.
Keywords: tau; related tauopathies; alzheimer disease; tau oligomers ... See more keywords
The prion-like transmission of tau oligomers via exosomes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.974414
Abstract: The conversion and transmission of misfolded proteins established the basis for the prion concept. Neurodegenerative diseases are considered “prion-like” disorders that lack infectivity. Among them, tauopathies are characterized by the conversion of native tau protein… read more here.
Keywords: tau; tau oligomers; prion like; transmission tau ... See more keywords