Association of MAPT Subhaplotypes With Risk of Progressive Supranuclear Palsy and Severity of Tau Pathology.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2019.0250
Abstract: Importance The association between the microtubule-associated protein tau (MAPT) H1 haplotype and the risk of progressive supranuclear palsy (PSP) has been well documented. However, the specific H1 subhaplotypes that drive the association have not been… read more here.
Keywords: risk; psp; tau pathology; pathology ... See more keywords
Association of Amyloid Reduction After Donanemab Treatment With Tau Pathology and Clinical Outcomes
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Neurology"
DOI: 10.1001/jamaneurol.2022.2793
Abstract: This post hoc analysis of the randomized clinical trial, Study of LY3002813 in Participants With Early Symptomatic Alzheimer’s Disease (TRAILBLAZER-ALZ), investigates if amyloid reduction from donanemab treatment is associated with slowing of tau pathology and… read more here.
Keywords: reduction donanemab; donanemab treatment; amyloid reduction; pathology ... See more keywords
18F‐Florzolotau Positron Emission Tomography Imaging of Tau Pathology in the Living Brains of Patients with Corticobasal Syndrome
Sign Up to like & getrecommendations! Published in 2023 at "Movement Disorders"
DOI: 10.1002/mds.29338
Abstract: Recent development in tau‐sensitive tracers has sparkled significant interest in tracking tauopathies using positron emission tomography (PET) biomarkers. However, the ability of 18F‐florzolotau PET imaging to topographically characterize tau pathology in corticobasal syndrome (CBS) remains… read more here.
Keywords: positron emission; pathology; 18f florzolotau; tau pathology ... See more keywords
Wolframin is a novel regulator of tau pathology and neurodegeneration
Sign Up to like & getrecommendations! Published in 2022 at "Acta Neuropathologica"
DOI: 10.1007/s00401-022-02417-4
Abstract: Selective neuronal vulnerability to protein aggregation is found in many neurodegenerative diseases including Alzheimer’s disease (AD). Understanding the molecular origins of this selective vulnerability is, therefore, of fundamental importance. Tau protein aggregates have been found… read more here.
Keywords: pathology; pathology neurodegeneration; wfs1; tau pathology ... See more keywords
Relevance of electroencephalogram assessment in amyloid and tau pathology in rat
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.10.026
Abstract: HighlightsThe rats express in hippocampus beta‐amyloid deposits and phosphorylated tau.On the 3rd month, a working memory impairment is observed by Morris water maze test.On the 3rd week, an overall decrease of the EEG bands power… read more here.
Keywords: amyloid tau; tau; tau pathology; beta amyloid ... See more keywords
Propagation of Tau Pathology: Integrating Insights From Postmortem and In Vivo Studies
Sign Up to like & getrecommendations! Published in 2020 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2019.09.019
Abstract: Cellular accumulation of aggregated forms of the protein tau is a defining feature of so-called tauopathies such as Alzheimer's disease, progressive supranuclear palsy, and chronic traumatic encephalopathy. A growing body of literature suggests that conformational… read more here.
Keywords: tau pathology; pathology; postmortem; pathology integrating ... See more keywords
Effect of tau-pathology on charged multivesicular body protein 2b (CHMP2B)
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research"
DOI: 10.1016/j.brainres.2018.11.008
Abstract: Charged multivesicular body protein 2b (CHMP2B) is a subunit of the endosomal sorting complex required for transport (ESCRT)-III that mediates scission of budded membranes. Neurons with CHMP2B-positive granulovacuolar inclusions in the cytoplasm are much more… read more here.
Keywords: gvd; tau pathology; pathology; transgenic mice ... See more keywords
Progressive tau aggregation does not alter functional brain network connectivity in seeded hTau.P301L mice
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2020.105011
Abstract: Progressive accumulation of hyperphosphorylated tau is a hallmark of various neurodegenerative disorders including Alzheimer's disease. However, to date, the functional effects of tau pathology on brain network connectivity have been investigated to a limited extent.… read more here.
Keywords: brain network; connectivity; tau pathology; pathology ... See more keywords
Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2017 at "Neuron"
DOI: 10.1016/j.neuron.2016.12.023
Abstract: The earliest stages of Alzheimer's disease (AD) are characterized by the formation of mature tangles in the entorhinal cortex and disorientation and confusion when navigating familiar places. The medial entorhinal cortex (MEC) contains specialized neurons… read more here.
Keywords: grid cell; alzheimer disease; tau pathology; pathology ... See more keywords
Astrocyte transport of glutamate and neuronal activity reciprocally modulate tau pathology in Drosophila
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2017.02.011
Abstract: Abnormal buildup of the microtubule associated protein tau is a major pathological hallmark of Alzheimer's disease (AD) and various tauopathies. The mechanisms by which pathological tau accumulates and spreads throughout the brain remain largely unknown.… read more here.
Keywords: drosophila; tau; tau pathology; deaat1 ... See more keywords
Physiological tau interactome in brain and its link to tauopathies.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.0c00137
Abstract: Alzheimer's disease (AD) and most of the other tauopathies are incurable neurodegenerative diseases with unpleasant symptoms and consequences. The common hallmark of all these diseases is tau pathology, but its connection with disease progress has… read more here.
Keywords: tau interacting; tau; physiological tau; tau pathology ... See more keywords