Association of Age at Menopause and Hormone Therapy Use With Tau and β-Amyloid Positron Emission Tomography.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2023.0455
Abstract: Importance Postmenopausal females represent around 70% of all individuals with Alzheimer disease. Previous literature shows elevated levels of tau in cognitively unimpaired postmenopausal females compared with age-matched males, particularly in the setting of high β-amyloid… read more here.
Keywords: tau pet; age menopause; age; menopause ... See more keywords
Sex Differences in Longitudinal Tau-PET in Preclinical Alzheimer Disease: A Meta-Analysis.
Sign Up to like & getrecommendations! Published in 2025 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2025.0013
Abstract: Importance Alzheimer disease (AD) predominates in females at almost twice the rate relative to males. Mounting evidence in adults without AD indicates that females exhibit higher tau deposition than age-matched males, particularly in the setting… read more here.
Keywords: tau pet; sex differences; tau; sex ... See more keywords
Clinical validity of second-generation tau PET tracers as biomarkers for Alzheimer’s disease in the context of a structured 5-phase development framework
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-020-05156-4
Abstract: In 2017, the Geneva Alzheimer’s disease (AD) strategic biomarker roadmap initiative proposed a framework of the systematic validation AD biomarkers to harmonize and accelerate their development and implementation in clinical practice. Here, we use this… read more here.
Keywords: tau pet; phase; pet tracers; validity ... See more keywords
Exploring the origins of frequent tau-PET signal in vermal and adjacent regions
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-025-07199-x
Abstract: Off-target binding remains a significant challenge in tau-PET neuroimaging. While off-targets including monoamine oxidase enzymes and neuromelanin-containing cells have been identified, recent studies indicated a relevant binding of novel tau tracers to melanin-containing structures. To… read more here.
Keywords: pet signal; tau pet; 18f 2620; tau ... See more keywords
Quantitation of PET spatial extent as a potential adjunct to visual interpretation of [18F]flortaucipir imaging: TAU-SPEX
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-025-07384-y
Abstract: Among visually Tau-PET-positive scans, large variation exists in the size of the visually tau-positive area. Here, we propose a metric quantifying the spatial extent of visual Tau-PET-positivity, termed “TAU-SPEX”, and evaluate associations with visual read… read more here.
Keywords: 18f flortaucipir; tau pet; pathology; tau spex ... See more keywords
Current Progress and Future Directions in Non-Alzheimer's Disease Tau PET Tracers.
Sign Up to like & getrecommendations! Published in 2025 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.4c00319
Abstract: Alzheimer's disease (AD) and non-AD tauopathies are dominant public health issues driven by several factors, especially in the aging population. The discovery of first-generation radiotracers, including [18F]FDDNP, [11C]PBB3, [18F]flortaucipir, and the [18F]THK series, for the… read more here.
Keywords: disease; progress; pet tracers; tau pet ... See more keywords
Discriminatory ability of next-generation tau PET tracers for Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2021 at "Brain"
DOI: 10.1093/brain/awab120
Abstract: Abstract A next generation of tau PET tracers for the imaging of Alzheimer’s disease and other dementias has recently been developed. Whilst the new compounds have now entered clinical studies, there is limited information available… read more here.
Keywords: tau pet; alzheimer disease; generation tau; disease ... See more keywords
Phospho-tau with subthreshold tau-PET predicts increased tau accumulation rates in amyloid-positive individuals
Sign Up to like & getrecommendations! Published in 2022 at "Brain"
DOI: 10.1093/brain/awac329
Abstract: Abstract Different tau biomarkers become abnormal at different stages of Alzheimer’s disease, with CSF phospho-tau typically becoming elevated at subthreshold levels of tau-PET binding. To capitalize on the temporal order of tau biomarker-abnormality and capture… read more here.
Keywords: tau; tau pet; positive individuals; tau accumulation ... See more keywords
Predicting amyloid PET and tau PET stages with plasma biomarkers
Sign Up to like & getrecommendations! Published in 2023 at "Brain"
DOI: 10.1093/brain/awad042
Abstract: Abstract Staging the severity of Alzheimer’s disease pathology using biomarkers is useful for therapeutic trials and clinical prognosis. Disease staging with amyloid and tau PET has face validity; however, this would be more practical with… read more here.
Keywords: plasma biomarkers; tau pet; pet stages; pet ... See more keywords
Prospective longitudinal atrophy in Alzheimer’s disease correlates with the intensity and topography of baseline tau-PET
Sign Up to like & getrecommendations! Published in 2020 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aau5732
Abstract: Tau imaging with [18F]flortaucipir predicts the severity and topography of subsequent MRI cortical atrophy in patients with Alzheimer’s disease. Predictive PET Understanding the dynamic of the two major hallmark of Alzheimer’s disease (AD), tau protein… read more here.
Keywords: topography; tau pet; tau; disease ... See more keywords
A steep decline in diastolic blood pressure over early to mid-life is associated with tau-PET burden in dementia-free adults
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Alzheimer's Disease"
DOI: 10.1177/13872877251372561
Abstract: Background The relationship between blood pressure (BP) trajectories across early (∼40 years) into mid-life (∼55 years) and preclinical dementia has not previously been well studied using positron emission tomography (PET) imaging outcomes. Objective To examine… read more here.
Keywords: dementia; tau pet; early mid; life ... See more keywords