Association of Age at Menopause and Hormone Therapy Use With Tau and β-Amyloid Positron Emission Tomography.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2023.0455
Abstract: Importance Postmenopausal females represent around 70% of all individuals with Alzheimer disease. Previous literature shows elevated levels of tau in cognitively unimpaired postmenopausal females compared with age-matched males, particularly in the setting of high β-amyloid… read more here.
Keywords: tau pet; age menopause; age; menopause ... See more keywords
Clinical validity of second-generation tau PET tracers as biomarkers for Alzheimer’s disease in the context of a structured 5-phase development framework
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-020-05156-4
Abstract: In 2017, the Geneva Alzheimer’s disease (AD) strategic biomarker roadmap initiative proposed a framework of the systematic validation AD biomarkers to harmonize and accelerate their development and implementation in clinical practice. Here, we use this… read more here.
Keywords: tau pet; phase; pet tracers; validity ... See more keywords
Discriminatory ability of next-generation tau PET tracers for Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2021 at "Brain"
DOI: 10.1093/brain/awab120
Abstract: Abstract A next generation of tau PET tracers for the imaging of Alzheimer’s disease and other dementias has recently been developed. Whilst the new compounds have now entered clinical studies, there is limited information available… read more here.
Keywords: tau pet; alzheimer disease; generation tau; disease ... See more keywords
Phospho-tau with subthreshold tau-PET predicts increased tau accumulation rates in amyloid-positive individuals
Sign Up to like & getrecommendations! Published in 2022 at "Brain"
DOI: 10.1093/brain/awac329
Abstract: Abstract Different tau biomarkers become abnormal at different stages of Alzheimer’s disease, with CSF phospho-tau typically becoming elevated at subthreshold levels of tau-PET binding. To capitalize on the temporal order of tau biomarker-abnormality and capture… read more here.
Keywords: tau; tau pet; positive individuals; tau accumulation ... See more keywords
Predicting amyloid PET and tau PET stages with plasma biomarkers
Sign Up to like & getrecommendations! Published in 2023 at "Brain"
DOI: 10.1093/brain/awad042
Abstract: Abstract Staging the severity of Alzheimer’s disease pathology using biomarkers is useful for therapeutic trials and clinical prognosis. Disease staging with amyloid and tau PET has face validity; however, this would be more practical with… read more here.
Keywords: plasma biomarkers; tau pet; pet stages; pet ... See more keywords
Prospective longitudinal atrophy in Alzheimer’s disease correlates with the intensity and topography of baseline tau-PET
Sign Up to like & getrecommendations! Published in 2020 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aau5732
Abstract: Tau imaging with [18F]flortaucipir predicts the severity and topography of subsequent MRI cortical atrophy in patients with Alzheimer’s disease. Predictive PET Understanding the dynamic of the two major hallmark of Alzheimer’s disease (AD), tau protein… read more here.
Keywords: topography; tau pet; tau; disease ... See more keywords
Tau PET imaging: present and future directions
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurodegeneration"
DOI: 10.1186/s13024-017-0162-3
Abstract: Abnormal aggregation of tau in the brain is a major contributing factor in various neurodegenerative diseases. The role of tau phosphorylation in the pathophysiology of tauopathies remains unclear. Consequently, it is important to be able… read more here.
Keywords: pet tracers; tau pet; tau; pet imaging ... See more keywords
The implications of different approaches to define AT(N) in Alzheimer disease
Sign Up to like & getrecommendations! Published in 2020 at "Neurology"
DOI: 10.1212/wnl.0000000000009485
Abstract: Objective To compare different β-amyloid (Aβ), tau, and neurodegeneration (AT[N]) variants within the Swedish BioFINDER studies. Methods A total of 490 participants were classified into AT(N) groups. These include 53 cognitively unimpaired (CU) and 48… read more here.
Keywords: tau tau; tau; alzheimer disease; tau pet ... See more keywords
Characterizing Amyloid-Positive Individuals With Normal Tau PET Levels After 5 Years
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000200287
Abstract: Background and Objective Individuals with biomarker evidence of β-amyloid (Aβ) deposition are increasingly being enrolled in clinical treatment trials but there is a need to identify markers to predict which of these individuals will also… read more here.
Keywords: tau pet; positive individuals; normal tau; biomarker ... See more keywords
Tau PET correlates with different Alzheimer’s disease‐related features compared to CSF and plasma p‐tau biomarkers
Sign Up to like & getrecommendations! Published in 2021 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.202114398
Abstract: PET, CSF and plasma biomarkers of tau pathology may be differentially associated with Alzheimer's disease (AD)‐related demographic, cognitive, genetic and neuroimaging markers. We examined 771 participants with normal cognition, mild cognitive impairment or dementia from… read more here.
Keywords: csf plasma; tau pet; plasma; pathology ... See more keywords
The Overlap Index as a Means of Evaluating Early Tau PET Signal Reliability
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Nuclear Medicine"
DOI: 10.2967/jnumed.121.263136
Abstract: Visual Abstract In tau PET, a reliable method to detect early tau accumulation in the brain is crucial. Noise, artifacts, and off-target uptake impede detection of subtle true-positive ligand binding. We hypothesize that identifying voxels… read more here.
Keywords: tau; pet signal; tau pet; overlap index ... See more keywords