Outer membrane vesicles enhance tau phosphorylation and contribute to cognitive impairment
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29362
Abstract: Outer membrane vesicles (OMVs) are nanosized vesicles produced by the gut microbiota (GM). The GM is well‐known to be involved in the pathological process of Alzheimer's disease (AD). However, the mechanism of OMVs is not… read more here.
Keywords: membrane vesicles; tau phosphorylation; cognitive impairment; outer membrane ... See more keywords
Dihydrolipoamide dehydrogenase suppression induces human tau phosphorylation by increasing whole body glucose levels in a C. elegans model of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Brain Research"
DOI: 10.1007/s00221-018-5341-0
Abstract: The microtubule associated tau protein becomes hyperphosphorylated in Alzheimer’s disease (AD). While hyperphosphorylation promotes neurodegeneration, the cause and consequences of this abnormal modification are poorly understood. As impaired energy metabolism is an important hallmark of… read more here.
Keywords: suppression; human tau; alzheimer disease; tau phosphorylation ... See more keywords
Effect of AmyTrap, an amyloid-β binding drug, on Aβ induced mitochondrial dysfunction and tau phosphorylation in cultured neuroblastoma cells
Sign Up to like & getrecommendations! Published in 2020 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-019-00520-2
Abstract: Alzheimer’s Disease (AD) is the most common cause of dementia, affecting 25 million people worldwide. Accumulation of Amyloid-β (Aβ) in the mitochondria has been shown to adversely affect key enzymes including pyruvate dehydrogenase (PDH), succinate… read more here.
Keywords: tau; dysfunction; effect; amytrap ... See more keywords
MicroRNA-322 Cluster Promotes Tau Phosphorylation via Targeting Brain-Derived Neurotrophic Factor
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemical Research"
DOI: 10.1007/s11064-018-2475-1
Abstract: Brain-derived neurotrophic factor (BDNF) is a crucial regulator to support synaptic plasticity and neuronal survival, its significant decrease is a pathophysiological hallmark in Alzheimer’s disease (AD) brains and accounts for poor prognosis. MicroRNAs (miRNAs) interfere… read more here.
Keywords: brain derived; tau phosphorylation; mir 322; derived neurotrophic ... See more keywords
Verapamil Inhibits Ser202/Thr205 Phosphorylation of Tau by Blocking TXNIP/ROS/p38 MAPK Pathway
Sign Up to like & getrecommendations! Published in 2017 at "Pharmaceutical Research"
DOI: 10.1007/s11095-017-2276-2
Abstract: PurposeOxidative stress is a hallmark of Alzheimer’s Disease (AD) and promotes tau phosphorylation. Since Thioredoxin Interacting protein (TXNIP), the inhibitor of the anti-oxidant system of Thioredoxin, is up regulated in the hippocampus of AD patients,… read more here.
Keywords: p38 mapk; ser202 thr205; verapamil; tau phosphorylation ... See more keywords
Nimodipine attenuates tau phosphorylation at Ser396 via miR‐132/GSK‐3&bgr; pathway in chronic cerebral hypoperfusion rats
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2017.10.027
Abstract: ABSTRACT Chronic cerebral hypofusion (CCH) promotes hyperphosphorylation of tau proteins, a key neuropathological trait that reflects neurodegenerative disorders. Nimodipine, an L‐type calcium channel antagonist, has been reported to show neuroprotective effects. In this study, we… read more here.
Keywords: tau phosphorylation; gsk bgr; phosphorylation ser396; mir 132 ... See more keywords
Old age potentiates cold-induced tau phosphorylation: linking thermoregulatory deficit with Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2016.09.024
Abstract: Thermoregulatory deficits coincide with a rise in the incidence of Alzheimer's disease (AD) in old age. Lower body temperature increases tau phosphorylation, a neuropathological hallmark of AD. To determine whether old age potentiates cold-induced tau… read more here.
Keywords: induced tau; cold induced; old age; tau phosphorylation ... See more keywords
Sauna-like conditions or menthol treatment reduce tau phosphorylation through mild hyperthermia
Sign Up to like & getrecommendations! Published in 2022 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2022.02.011
Abstract: In Alzheimer's disease (AD), hyper-phosphorylation and aggregation of tau correlate with clinical progression and represent a valid therapeutic target. A recent 20-year prospective study revealed an association between moderate to high frequency of Finnish sauna… read more here.
Keywords: conditions menthol; menthol treatment; phosphorylation; like conditions ... See more keywords
Pharmacological inhibition of PTEN attenuates cognitive deficits caused by neonatal repeated exposures to isoflurane via inhibition of NR2B-mediated tau phosphorylation in rats
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2016.11.008
Abstract: ABSTRACT Evidence has shown that children exposed to repeated anesthesia in early childhood display long‐term cognitive disabilities. However, the underlying mechanisms remain largely unclear. Our previous study has indicated the involvement of phosphatase and tensin… read more here.
Keywords: pten; inhibition; neonatal repeated; tau phosphorylation ... See more keywords
Inhibition of 5α Reductase Impairs Cognitive Performance, Alters Dendritic Morphology and Increases Tau Phosphorylation in the Hippocampus of Male 3xTg-AD Mice
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2020.01.011
Abstract: Recent work has suggested that 5α-reduced metabolites of testosterone may contribute to the neuroprotection conferred by their parent androgen, as well as to sex differences in the incidence and progression of Alzheimer's disease (AD). This… read more here.
Keywords: dendritic morphology; mice; tau phosphorylation; male 3xtg ... See more keywords
Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00382
Abstract: Structural analysis of the known NIK inhibitor 3 bound to the kinase domain of TTBK1 led to the design and synthesis of a novel class of azaindazole TTBK1 inhibitors exemplified by 8 (cell IC50: 571… read more here.
Keywords: tau; discovery potent; ttbk1 inhibitors; kinase ... See more keywords