Pick's disease with neuronal four‐repeat tau accumulation in the basal ganglia, brain stem nuclei and cerebellum
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DOI: 10.1111/neup.12394
Abstract: It is very rare that cases of Pick's disease, a representative three‐repeat (3R) tauopathy, also have significant four‐repeat (4R) tau accumulation. Here, we report a Pick's disease case that clinically showed behavioral variant frontotemporal dementia… read more here.
Keywords: tau positive; tau; repeat; pathology ... See more keywords
Astrocytic tau pathologies in aged human brain
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DOI: 10.1111/neup.12544
Abstract: Argyrophilic and tau‐positive abnormal structures in astrocytes are frequent in aged brains, with a new nomenclature of aging‐related tau astrogliopathy (ARTAG) proposed. The two major cytomorphologies of ARTAG are thorn‐shaped astrocytes (TSA) and granular or… read more here.
Keywords: tau positive; tau; tau tau; tau negative ... See more keywords
Tau Positive Neurons Show Marked Mitochondrial Loss and Nuclear Degradation in Alzheimer's Disease.
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DOI: 10.2174/1567205015666180613115644
Abstract: BACKGROUND Alzheimer's disease (AD) pathology consists of intraneuronal neurofibrillary tangles, made of hyperphosphorylated tau and extracellular accumulation of beta amyloid (Aβ) in Aβ plaques. There is an extensive debate as to which pathology initiates and… read more here.
Keywords: tau positive; tau; tau neurons; pathology ... See more keywords