Impedance Spectroscopy for Identifying Tau-protein to Monitor Anesthesia-based Issues.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2246
Abstract: Anesthesia-related drugs cause various side effects and health-related illnesses after surgery. In particular, neurogenerative disorder is a common problem of anesthesia-related drugs. A patient undergoes anesthesia as a requirement of the preoperative evaluation to diagnose… read more here.
Keywords: impedance spectroscopy; anesthesia related; tau protein; spectroscopy ... See more keywords
Tau protein is differentially phosphorylated in young‐ and old‐aged rats with experimentally induced hyperthyroidism
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Developmental Neuroscience"
DOI: 10.1002/jdn.10220
Abstract: Aging involves progressive physiological changes, including thyroid dysfunction; thus, changes in plasma thyroid hormone (TH) level may affect neuronal function such as synaptic plasticity and Tau phosphorylation. However, how Tau protein is modulated in hyperthyroidism… read more here.
Keywords: tau; experimentally induced; rats experimentally; young old ... See more keywords
Functional role of the Tau protein in epithelial ovarian cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "Reproductive Medicine and Biology"
DOI: 10.1002/rmb2.12019
Abstract: The microtubule‐associated Tau protein is a marker of paclitaxel sensitivity in ovarian cancer. The aim of the present study was to elucidate the function of the Tau protein in epithelial ovarian cancer. read more here.
Keywords: protein epithelial; epithelial ovarian; ovarian cancer; tau protein ... See more keywords
The Study of Posttranslational Modifications of Tau Protein by Nuclear Magnetic Resonance Spectroscopy: Phosphorylation of Tau Protein by ERK2 Recombinant Kinase and Rat Brain Extract, and Acetylation by Recombinant Creb-Binding Protein.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6598-4_11
Abstract: Nuclear magnetic resonance (NMR) spectroscopy can be used as an analytical tool to investigate posttranslational modifications of protein. NMR is a valuable tool to map the interaction regions of protein partners. Here, we present protocols… read more here.
Keywords: protein; spectroscopy; posttranslational modifications; phosphorylation ... See more keywords
Comparison of the force fields on monomeric and fibrillar PHF6 of tau protein.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical chemistry"
DOI: 10.1016/j.bpc.2021.106631
Abstract: The hexapeptide 306VQIVYK311 (PHF6) plays an important role in the aggregation of Tau protein, which is a hallmark of the Alzheimer's disease (AD). In this article, we systematically compare the effects of eight popular all-atom… read more here.
Keywords: phf6; fields monomeric; force fields; fibrillar phf6 ... See more keywords
Tau protein aggregation: key features to improve drug discovery screening.
Sign Up to like & getrecommendations! Published in 2022 at "Drug discovery today"
DOI: 10.1016/j.drudis.2022.01.009
Abstract: Tauopathies are neurodegenerative disorders associated with the accumulation of abnormal tubulin associated unit (tau) protein in the brain. Tau pathologies include a broad spectrum of diseases, with Alzheimer's disease (AD) being the most common tauopathy.… read more here.
Keywords: aggregation; tau protein; drug discovery;
Interaction of metal ions with tau protein. The case for a metal-mediated tau aggregation.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2019.02.007
Abstract: Tau protein aggregation and its hyperphosphorylation play an important role in the pathogenesis of Alzheimer's disease. There is also considerable evidence for the accumulation of Fe2/3+, Cu2+, and Zn2+ in the brain of Alzheimer's patients,… read more here.
Keywords: aggregation; ions tau; metal ions; interaction metal ... See more keywords
Copper (II) binding properties of an octapeptide fragment from the R3 region of tau protein: A combined potentiometric, spectroscopic and mass spectrometric study.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2021.111358
Abstract: The copper(II) complexes of a peptide fragment of the R3 domain of tau protein (tau(326-333) Ac-GNIHHKPG-NH2) and its mutants (Ac-GNGHHKPG-NH2, Ac-GNIHHKAG-NH2, Ac-GNGAHKPG-NH2 and Ac-GNGHAKPG-NH2) have been studied by potentiometric and spectroscopic (UV-Vis, CD) methods. ESR… read more here.
Keywords: protein; copper binding; copper; spectroscopic ... See more keywords
Neuroprotective effect of epalrestat mediated through oxidative stress markers, cytokines and TAU protein levels in diabetic rats
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.06.021
Abstract: Aims: Type‐2 diabetes mellitus (DM) is associated with cognitive impairment. Increasing evidence establishes that neuro‐inflammatory and oxidative stress condition plays a main role in the development of neurodegeneration. Epalrestat, an aldose reductase inhibitor is commonly… read more here.
Keywords: epalrestat; protein levels; diabetic rats; tau protein ... See more keywords
Serum and saliva total tau protein as a marker for relapsing-remitting multiple sclerosis.
Sign Up to like & getrecommendations! Published in 2019 at "Medical hypotheses"
DOI: 10.1016/j.mehy.2019.109476
Abstract: Multiple sclerosis (MS) is considered as motor and sensory function loss, which results from demyelination and following axonal lesion. Tau protein interferes in the construction and stabilization of microtubules that are needed for axonal transport.… read more here.
Keywords: protein; saliva total; total tau; serum ... See more keywords
Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2019 at "Neuron"
DOI: 10.1016/j.neuron.2018.12.031
Abstract: Bahareh Eftekharzadeh, J. Gavin Daigle, Larisa E. Kapinos, Alyssa Coyne, Julia Schiantarelli, Yari Carlomagno, Casey Cook, Sean J. Miller, Simon Dujardin, Ana S. Amaral, Jonathan C. Grima, Rachel E. Bennett, Katharina Tepper, Michael DeTure, Charles… read more here.
Keywords: alzheimer disease; protein disrupts; disrupts nucleocytoplasmic; nucleocytoplasmic transport ... See more keywords